O'Rourke A M, Mescher M F
Medical Biology Institute, La Jolla, CA.
Immunol Today. 1993 Apr;14(4):183-8. doi: 10.1016/0167-5699(93)90283-q.
The CD8 glycoprotein of cytotoxic T cells is both an adhesion protein and a cosignalling receptor. These functions are regulated by signals from the T-cell antigen receptor complex (TCR-CD3), and CD8 acts to couple TCR occupancy to second messenger pathways. Here Anne O'Rourke and Matthew Mescher examine the roles of CD8 in activating the adhesion and signalling cascade initiated by antigen binding.
细胞毒性T细胞的CD8糖蛋白既是一种黏附蛋白，也是一种共信号受体。这些功能受来自T细胞抗原受体复合物（TCR-CD3）信号的调节，并且CD8起到将TCR占据与第二信使途径相偶联的作用。在此，安妮·奥罗克和马修·梅舍尔研究了CD8在激活由抗原结合引发的黏附及信号级联反应中的作用。
