Andrade Z A, Cheever A W
Gonçalo Moniz Research Center (FIOCRUZ), Salvador, Bahia, Brazil.
Int J Exp Pathol. 1993 Apr;74(2):195-202.
During mild (one to two pairs of worms) and prolonged (23 weeks or more) mouse infections with Schistosoma mansoni, but not with S. japonicum, periovular granulomas and fibrosis were seen to be preferentially located along periportal tissues. This caused fibrotic expansion of the portal spaces on a background of normal-looking hepatic parenchyma, a picture mimicking 'clay pipestem fibrosis' seen in human patients with advanced schistosomiasis. The model was reproduced in outbred and in several strains of inbred mice, and their main characteristics were studied and compared to the human counterpart. A balanced consideration of the similarities and differences between the murine model and human pipestem fibrosis is needed for the adequate utilization of this simple, reproducible and inexpensive experimental model.
在用曼氏血吸虫轻度（一到两对虫体）且长期（23周或更长时间）感染小鼠的过程中，但日本血吸虫感染则不会出现这种情况，可见卵周肉芽肿和纤维化优先位于门周组织。这导致在看似正常的肝实质背景下门管区发生纤维化扩张，这种情况类似于晚期血吸虫病患者中所见的“泥烟斗样纤维化”。该模型在远交系和几种近交系小鼠中均可复制，对其主要特征进行了研究，并与人类情况进行了比较。为了充分利用这个简单、可复制且廉价的实验模型，需要对小鼠模型与人类泥烟斗样纤维化之间的异同进行全面考量。
