Rångemark C, Ciabattoni G, Wennmalm A
Department of Clinical Physiology, Gothenburg University, Sweden.
Arterioscler Thromb. 1993 Jun;13(6):777-82. doi: 10.1161/01.atv.13.6.777.
Cigarette smokers, but not former smokers, excrete more thromboxane A2 (TxA2) metabolites in the urine than do lifelong nonsmokers, which suggests chronic activation of their platelets. To further characterize the effect elicited by smoking on platelet function, we followed the change in urinary excretion of the 2,3-dinor (Tx-M) and 11-dehydro (dTx) metabolites of TxA2, analyzed by gas chromatography/mass spectrometry and radioimmunoassay, respectively, in eight healthy women who quit habitual smoking and compared it with the recovery of these metabolites after a single dose of acetylsalicylic acid (ASA). Tx-M and dTx before cessation of smoking were approximately 550 and 600 pg/mg creatinine, respectively. Within 3 days after quitting smoking, Tx-M and dTx had dropped to stable levels of approximately 300 and 350 pg/mg, respectively. The rates of change in excretion of Tx-M and dTx after smoking cessation were more rapid (p < 0.02 and 0.02, respectively) than those observed during the recovery of platelet function after a single dose of ASA. The excretion of 2,3-dinor-6-keto-prostaglandin F1 alpha, a metabolite of prostacyclin, was not affected by smoking cessation. We conclude that cigarette smoking elicits an increase in platelet activity in the absence of vascular injury. This increase is reversible within the life span of the platelets.
与终生不吸烟者相比，吸烟者（而非曾经吸烟但现已戒烟者）尿中血栓素A2（TxA2）代谢产物的排泄量更多，这表明其血小板处于慢性激活状态。为进一步明确吸烟对血小板功能的影响，我们对8名习惯性戒烟的健康女性进行了跟踪研究，分别采用气相色谱/质谱分析法和放射免疫分析法，测定她们尿中TxA2的2,3-二羟基代谢产物（Tx-M）和11-脱氢代谢产物（dTx）的排泄变化，并将其与单次服用乙酰水杨酸（ASA）后这些代谢产物的恢复情况进行比较。戒烟前，Tx-M和dTx的水平分别约为550和600 pg/mg肌酐。戒烟后3天内，Tx-M和dTx分别降至约300和350 pg/mg的稳定水平。戒烟后Tx-M和dTx排泄量的变化速率比单次服用ASA后血小板功能恢复期间的变化速率更快（分别为p < 0.02和0.02）。前列环素的代谢产物2,3-二羟基-6-酮-前列腺素F1α的排泄不受戒烟影响。我们得出结论，吸烟在无血管损伤的情况下会导致血小板活性增加。这种增加在血小板的寿命范围内是可逆的。
