Jáuregui A, Martínez Palacios M L, Arnaiz I, Pontón J, Cisterna R
Departamento de Microbiología e Inmunología, Facultad de Medicina, Universidad del País Vasco, Bilbao.
Enferm Infecc Microbiol Clin. 1993 Mar;11(3):126-30.
To evaluate a new chitin detection technique for the quantification of Aspergillus fumigatus infection in organs from air-borne infected mice.
Different groups of mice were air-borne infected with A. fumigatus spores. The mortality rate was studied as well as the extension of the infection by means of colony counts (UFC) and quantification of chitin .
The inhalation of A. fumigatus spores by non-immunosuppressed mice produces a 34% mortality rate, with an initial invasion of lung tissue followed by the spleen, kidneys, heart and liver thereafter.
The quantification of chitin in involved organs allowed us to estimate the degree of organ-specific fungal infections and perhaps could be an useful method for studying the pathogenesis of A. fumigatus infections.
评估一种新的几丁质检测技术，用于定量检测经空气传播感染的小鼠器官中烟曲霉感染情况。
将不同组的小鼠经空气传播感染烟曲霉菌孢子。研究死亡率，并通过菌落计数（UFC）和几丁质定量来研究感染的扩散情况。
未免疫抑制的小鼠吸入烟曲霉菌孢子后，死亡率为34%，最初肺组织受到侵袭，随后脾脏、肾脏、心脏和肝脏也受到感染。
对受累器官中的几丁质进行定量分析，使我们能够估计器官特异性真菌感染的程度，这可能是研究烟曲霉感染发病机制的一种有用方法。
