Champault G, Belghiti J, Legout J, Patel J C
J Chir (Paris). 1977;113(1):67-84.
The abusive and inappropriate use of antibiotics in digestive surgery has led to the selection of multi-resistant strains responsible for sometimes dramatic infective complications. The study of the normal digestive flora under pathological conditions, knowledge of the mechanisms of resistance, led us to propose the use of antibiotics with circumspection, depending on the germ isolated and the probable efficacy of the drugs. Prophylactic antibiotic therapy is only justified with regard to gram positive anaerobic bacteria or, in exceptional cases, where the risk seems high and may irremediably compromise the surgical procedure. Curative antibiotic therapy, after treatment of the infective focus, is often sufficient but depends on the bacteria: Whether anaerobic, staphylococci of Gram negative bacilli, with regard to which one should use narrow spectrum single antibiotics.
消化外科中对抗生素的滥用和不当使用导致了多重耐药菌株的出现,这些菌株有时会引发严重的感染性并发症。对病理条件下正常消化菌群的研究以及对抗菌机制的了解,促使我们根据分离出的病菌和药物的可能疗效谨慎使用抗生素。预防性抗生素治疗仅在针对革兰氏阳性厌氧菌时或在极少数风险似乎很高且可能不可挽回地影响手术过程的情况下才合理。在治疗感染病灶后进行的治愈性抗生素治疗通常就足够了,但这取决于细菌类型:无论是厌氧菌、革兰氏阴性杆菌葡萄球菌,针对这些细菌应使用窄谱单一抗生素。