Zhou J X, Liu R, Yang S X
Second Affiliated Hospital, Xi'an Medical University.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Jan;13(1):36-8, 6.
In exploring the effect of treatment of supporting the body resistance on chronic renal failure, a chronic renal failure model of rat was created by gastroperfusion of adenine and evaluation was made on the therapeutic effect of Kidney Invigorating and Lipid Reducing Decoction (KILRD). The mental state and body weight of the treated group have recovered well with polyuria and proteinurea improving, BUN and Creatinine decreasing, which appeared to be superior to the naturally recovered group. Renal pathological examination showed that: although the renal parenchymal damage was not reversed but its compensation was satisfactory with compensatory hypertrophy appearing in unaffected nephron. The dominant reaction in the affected area was polynucleomacrocytosis, foreign body granulamatosis, and interstitial lymphocytic infiltration, the fibrosis was inevident, while the above-mentioned condition in the naturally recovered group was relatively more serious, with fibrosis being observed. It was indicated that KILRD could increase the compensatory capacity and immunity, promote protein synthetization and improve renal function. The study on KILRD proved to be a significant conservative medical treatment for chronic renal failure.
为探讨扶正疗法对慢性肾衰竭的治疗作用，采用腺嘌呤胃灌注法复制大鼠慢性肾衰竭模型，并对益肾降脂汤（KILRD）的治疗效果进行评价。治疗组大鼠精神状态和体重恢复良好，多尿、蛋白尿改善，血尿素氮（BUN）和肌酐降低，疗效优于自然恢复组。肾脏病理检查显示：虽然肾实质损伤未逆转，但代偿良好，未受影响的肾单位出现代偿性肥大。病变区域主要表现为多核巨噬细胞增多、异物肉芽肿形成和间质淋巴细胞浸润，纤维化不明显，而自然恢复组上述情况相对较重，可见纤维化。提示益肾降脂汤可提高代偿能力和免疫力，促进蛋白质合成，改善肾功能。益肾降脂汤治疗慢性肾衰竭的研究是一种有意义的保守治疗方法。
