Zeruesenay D, Siegmund W, Franke G, Zschiesche M
Gondar College of Medical Sciences, Addis Abada University, Ethiopia.
Chronobiol Int. 1993 Apr;10(2):81-6. doi: 10.1080/07420529309059695.
The pharmacokinetics of theophylline (TPH, 10 mg/kg i.v.) were assessed in rats (natural light-dark span, June 9-10) after i.p. pretreatment with saline and 80 mg/kg phenobarbital (PB), respectively, for 3 consecutive days at either 07:00 h or at 19:00 h. Serum concentrations of TPH were assayed by high-performance liquid chromatography. No significant differences of the elimination rates of TPH could be found between the times of TPH administration (clearance: 1.17 +/- 0.17 ml/kg/min at 07:00 h vs. 1.23 +/- 0.17 ml/kg/min at 19:00 hours). PB premedication markedly accelerated TPH elimination. The increase in clearance values was more expressed when TPH was injected at 07:00 h than at 19:00 h (2.48 +/- 0.67 vs. 2.06 +/- 0.41 ml/kg/min, p < 0.01).
分别于上午7点或晚上7点，用生理盐水和80毫克/千克苯巴比妥（PB）对大鼠（自然光暗周期，6月9日至10日）进行连续3天的腹腔注射预处理后，评估茶碱（TPH，静脉注射10毫克/千克）的药代动力学。采用高效液相色谱法测定血清中TPH的浓度。TPH给药时间之间未发现TPH消除率有显著差异（清除率：上午7点时为1.17±0.17毫升/千克/分钟，晚上7点时为1.23±0.17毫升/千克/分钟）。PB预处理显著加速了TPH的消除。当上午7点注射TPH时，清除率的增加比晚上7点注射时更明显（2.48±0.67对2.06±0.41毫升/千克/分钟，p<0.01）。
