Cupková V, Sirotková L, Mlynarcík D, Devínsky F, Lacko I, Kovacková Z
Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.
Folia Microbiol (Praha). 1993;38(1):43-8. doi: 10.1007/BF02814548.
Biodegradation of two amphiphilic "soft" antimicrobially active derivatives of lauric (dodecanoic) acid, a quaternary ammonium salt and an amine oxide bearing an amide or ester group, was followed using microorganisms from activated sludge. Primary biodegradation was determined by ion-selective electrodes, total biodegradation as the chemical oxygen demand. Though organic ammonium salts quickly undergo primary biodegradation, the rest of the molecule is difficult to destroy. In contrast, amine oxides are easily biodegradable.
采用活性污泥中的微生物，对月桂酸（十二烷酸）的两种两亲性“软质”抗菌活性衍生物（一种季铵盐和一种带有酰胺或酯基的氧化胺）的生物降解情况进行了跟踪研究。通过离子选择电极测定初级生物降解，以化学需氧量测定总生物降解。虽然有机铵盐能迅速进行初级生物降解，但分子的其余部分难以被破坏。相比之下，氧化胺易于生物降解。
