Walker C B, Nitzan D, Wilkins T D
Antimicrob Agents Chemother. 1977 Mar;11(3):435-40. doi: 10.1128/AAC.11.3.435.
The efficacies of five common antimicrobial agents were determined for a pure Bacteroides fragilis infection in mice. Therapy was begun 4 h after bacterial injection and given every 8 h thereafter for 5 days. Blood levels were determined over an 8-h period for each concentration of antibiotic tested. Clindamycin and tetracycline were the most effective in preventing the formation of abscesses. Chloramphenicol, penicillin G, and cephalothin were not effective in protecting the mice from infection.
测定了五种常见抗菌剂对小鼠脆弱拟杆菌纯感染的疗效。在细菌注射后4小时开始治疗，此后每8小时给药一次，持续5天。对每种测试浓度的抗生素，在8小时内测定血药浓度。克林霉素和四环素在预防脓肿形成方面最有效。氯霉素、青霉素G和头孢噻吩在保护小鼠免受感染方面无效。
