Price J, O'Day J
Neuro-ophthalmology Department, St. Vincent's Hospital, Melbourne, Australia.
J Clin Neuroophthalmol. 1993 Mar;13(1):67-71.
In the neuro-ophthalmology clinic at St. Vincent's Hospital, Melbourne, 57 patients with blepharospasm and 50 patients with hemifacial spasm were treated with botulinum toxin. Schirmer tear tests were conducted on all the patients prior to each treatment and at 1 week following treatment where possible. The results were compared with a control group of 107 patients selected by age and sex. The blepharospasm patients were found to have a significantly lower tear secretion than that of the control group, using the Mann-Whitney test (median = 3.5 mm, compared with median-11.0 mm, p < .0001). This did not improve following treatment. The patients with hemifacial spasm did not have significantly different tear secretion from that of the control group (t = 1.0, p > .05). To investigate whether there was any relationship between the symptoms and the result of the Schirmer test, a survey was also conducted on the patients with blepharospasm and hemifacial spasm regarding symptoms, frequency, and type of drops/ointment used.
在墨尔本圣文森特医院的神经眼科诊所，57例眼睑痉挛患者和50例半面痉挛患者接受了肉毒杆菌毒素治疗。在每次治疗前及尽可能在治疗后1周对所有患者进行了泪液分泌试验（Schirmer试验）。将结果与按年龄和性别选取的107例患者组成的对照组进行比较。采用曼-惠特尼检验发现，眼睑痉挛患者的泪液分泌明显低于对照组（中位数 = 3.5毫米，对照组中位数为11.0毫米，p < .0001）。治疗后这一情况并未改善。半面痉挛患者的泪液分泌与对照组无显著差异（t = 1.0，p > .05）。为了研究症状与Schirmer试验结果之间是否存在任何关系，还对眼睑痉挛和半面痉挛患者就症状、频率以及所使用滴眼液/眼膏的类型进行了调查。
