Price J, O'Day J
St Vincent's Hospital, Melbourne, Victoria.
Aust N Z J Ophthalmol. 1994 Nov;22(4):255-60. doi: 10.1111/j.1442-9071.1994.tb00793.x.
To analyse the effectiveness and rate of side effects of botulinum toxin treatment for blepharospasm and hemifacial spasm.
In a prospective trial, 81 patients with blepharospasm and 70 with hemifacial spasm were treated with botulinum toxin A in the neuroophthalmology clinic at St Vincent's Hospital, Melbourne. Some 989 treatments were given and the mean follow-up time was 28.7 months.
The duration of action was longer for patients with hemifacial spasm than for those with blepharospasm (median 12.0 weeks compared with 7.0 weeks, P < 0.0001). There was no change in the duration of effect over time with repeated treatments of the same dose (F = 0.4, P > 0.05). Once an effective dosage was reached, increasing the dose further did not prolong the duration of effect. There were no systemic side effects, but there were a number of local transient side effects. The most significant side effect was ptosis, which occurred in 12% of treatments given to those patients with blepharospasm and hemifacial spasm.
Botulinum toxin is an effective treatment for blepharospasm and hemifacial spasm, but there are a number of side effects, the most significant being ptosis.
分析肉毒杆菌毒素治疗眼睑痉挛和半面痉挛的有效性及副作用发生率。
在一项前瞻性试验中，墨尔本圣文森特医院神经眼科门诊对81例眼睑痉挛患者和70例半面痉挛患者采用A型肉毒杆菌毒素进行治疗。共进行了约989次治疗，平均随访时间为28.7个月。
半面痉挛患者的作用持续时间比眼睑痉挛患者长（中位数分别为12.0周和7.0周，P < 0.0001）。相同剂量重复治疗时，效果持续时间未随时间改变（F = 0.4，P > 0.05）。达到有效剂量后，进一步增加剂量并不能延长效果持续时间。未出现全身性副作用，但有一些局部短暂性副作用。最显著的副作用是上睑下垂，在眼睑痉挛和半面痉挛患者接受的治疗中，有12%出现了该副作用。
肉毒杆菌毒素是治疗眼睑痉挛和半面痉挛的有效方法，但存在一些副作用，最显著的是上睑下垂。
