Witkin S S, Jeremias J, Toth M, Ledger W J
Dept. of Obstetrics and Gynecology, Cornell University Medical College, New York, NY 10021.
J Infect Dis. 1993 Jun;167(6):1379-83. doi: 10.1093/infdis/167.6.1379.
Peripheral blood mononuclear cells (PBMC) from 9 of 18 women with laparoscopy-verified salpingitis proliferated in response to recombinant Chlamydia trachomatis 57-kDa heat shock protein (hsp). In contrast, PBMC from 0 of 10 women with cervicitis, 1 of 5 women with recurrent abortions, and 3 (7.1%) of 42 healthy reproductive-age women were responsive to hsp (P < .001). After passage of the hsp through an endotoxin-removing column, PBMC from 6 of 14 additional women with salpingitis were responsive to hsp, while those from 10 controls, including the 3 previously positive women, were negative. PBMC from all patients responsive to the chlamydial hsp were unresponsive to Mycobacterium bovis 65-kDa hsp. PBMC from 6 of the 15 women with a positive hsp-induced lymphocyte response were unresponsive to C. trachomatis elementary bodies. Induction of a cell-mediated immune response to the chlamydial 57-kDa hsp is a common feature of an upper genital tract infection but does not appear to be limited to women with apparent chlamydial infections.
18名经腹腔镜检查证实患有输卵管炎的女性中，有9人的外周血单个核细胞（PBMC）对重组沙眼衣原体57-kDa热休克蛋白（hsp）产生增殖反应。相比之下，10名宫颈炎女性、5名复发性流产女性中的0人以及42名健康育龄女性中的3人（7.1%）的PBMC对hsp有反应（P <.001）。hsp通过内毒素去除柱后，另外14名输卵管炎女性中的6人的PBMC对hsp有反应，而包括之前3名阳性女性在内的10名对照者的PBMC则无反应。所有对衣原体hsp有反应的患者来源的PBMC对牛分枝杆菌65-kDa hsp无反应。15名hsp诱导的淋巴细胞反应呈阳性的女性中，有6人的PBMC对沙眼衣原体原体无反应。对衣原体57-kDa hsp产生细胞介导免疫反应是上生殖道感染的一个常见特征，但似乎并不局限于明显患有衣原体感染的女性。
