Cherry J D, Holtzman A E, Shields W D, Buch D, Nielsen C, Jacobsen V, Christenson P D, Zachau-Christiansen B
Department of Pediatrics, University of California Los Angeles School of Medicine.
J Pediatr. 1993 Jun;122(6):900-3. doi: 10.1016/s0022-3476(09)90014-2.
In a previous study in which we examined the relationship of pertussis immunization to the onset of neurologic disorders during 1967 and 1968 and during 1972 and 1973 in Denmark, there were 554 children with initial onset of epilepsy and 2158 children with first febrile convulsions. In the study population there were 112 children with epilepsy and 229 children with febrile convulsions for whom the exact date of pertussis immunization and the exact date of the onset of illness were known. We analyzed selected clinical variables by specific time intervals between pertussis immunization and the first seizure. In the children with epilepsy, no relationship was found between time of pertussis immunization and the specific variables that were examined. In contrast, the following characteristics in children with febrile seizures were significantly more common when pertussis immunization had occurred within 3 days, compared with more than 7 days of the event: first seizure more than 10 minutes in duration, the occurrence of more than one seizure, the longest seizure (when there was more than one) more than 10 minutes in duration, and the occurrence of a seizure described as focal. The lack of specific characteristics in epilepsy that had its onset in a temporal relationship to pertussis immunization is further evidence that pertussis vaccine does not cause this disorder. The cause of increased severity of febrile seizures apparently associated with pertussis immunization is unknown.
在之前的一项研究中，我们调查了1967年和1968年以及1972年和1973年丹麦百日咳免疫接种与神经系统疾病发病之间的关系。其中有554名首次发作癫痫的儿童和2158名首次热性惊厥的儿童。在研究人群中，有112名癫痫儿童和229名热性惊厥儿童，其百日咳免疫接种的确切日期和疾病发作的确切日期是已知的。我们按百日咳免疫接种与首次发作之间的特定时间间隔分析了选定的临床变量。在癫痫儿童中，未发现百日咳免疫接种时间与所检查的特定变量之间存在关联。相比之下，与事件发生7天以上相比，百日咳免疫接种在3天内发生时，热性惊厥儿童的以下特征明显更为常见：首次发作持续超过10分钟、发作不止一次、最长发作（如果发作不止一次）持续超过10分钟以及出现局灶性发作。与百日咳免疫接种存在时间关系的癫痫缺乏特定特征，这进一步证明百日咳疫苗不会引发这种疾病。与百日咳免疫接种明显相关的热性惊厥严重程度增加的原因尚不清楚。
