LaRosa J A, Saywell R M, Zollinger T W, Oser T L, Erner B K, McClain E
St. Vincent Hospital and Health Care Center, Indianapolis, Indiana.
J Reprod Med. 1993 Apr;38(4):293-300.
With the current clinical popularity of patient-controlled analgesia pumps (PCAP) in postoperative pain management, it is prudent to be aware of the possible risk of adynamic ileus formation from intravenous narcotic administration. We hypothesized that prolonged PCAP exposure could delay bowel motility and increase post-operative morbidity. After stringent exclusionary parameters were met, we retrospectively analyzed 170 postcesarean patients who received PCAP medication and compared data with 171 postcesarean patients who received traditional intramuscular (IM) administration. The degree of adynamic ileus formation of moderate and severe intensity was higher in PCAP users (21.8%) vs. IM users (13.5%), P = .02. There was no significant difference in the average cumulative amount of analgesic administered during the first 24 postoperative hours for PCAP (442.2 mg) vs. IM (397.7 mg), reflecting that the mode of narcotic delivery is responsible for ileus formation rather than the dosage. Type of postoperative diet and speed of diet advancement were also factored into the analysis and did not statistically influence the results. We conclude that PCAP usage may increase the morbidity risk for adynamic ileus formation, and that usage should be accompanied with close monitoring of bowel motility.
鉴于目前患者自控镇痛泵(PCAP)在术后疼痛管理中在临床上的广泛应用,了解静脉注射麻醉剂导致动力性肠梗阻形成的潜在风险是很有必要的。我们假设长时间使用PCAP会延迟肠道蠕动并增加术后发病率。在满足严格的排除标准后,我们回顾性分析了170例接受PCAP药物治疗的剖宫产术后患者,并将数据与171例接受传统肌肉注射(IM)的剖宫产术后患者进行比较。PCAP使用者中中度和重度动力性肠梗阻形成的程度高于IM使用者(21.8%对13.5%),P = 0.02。术后24小时内PCAP组(442.2毫克)和IM组(397.7毫克)的平均累积镇痛药物用量无显著差异,这表明麻醉剂的给药方式而非剂量是导致肠梗阻形成的原因。术后饮食类型和饮食推进速度也纳入了分析,且对结果无统计学影响。我们得出结论,使用PCAP可能会增加动力性肠梗阻形成的发病风险,使用时应密切监测肠道蠕动。