丝裂霉素C联合睾丸切除术治疗新诊断的转移性前列腺癌：一项随机试验的初步结果
Mitomycin C in combination with orchiectomy for newly diagnosed metastatic prostate cancer: preliminary results on a randomized trial.
作者信息
Van Poppel H, van den Broucke F, Derluyn J, Popelier G, Casselman J, Billiet I, van Uytsel L, Paridaens R, Baert L
机构信息
Department of Urology, University Hospitals Katholieke Universiteit Leuven, Belgium.
出版信息
J Urol. 1993 Jun;149(6):1485-7. doi: 10.1016/s0022-5347(17)36423-6.
The preliminary results of a randomized trial comparing orchiectomy versus orchiectomy and mitomycin C in 119 newly diagnosed metastatic prostate cancer patients are presented. Of 109 evaluable patients 57 were treated with orchiectomy alone and 52 received adjuvant intravenous mitomycin C. Mean interval to progression was 13 months in the orchiectomy group versus 11 months in the mitomycin C group. Preliminary analysis did not demonstrate a favorable effect of the combination with this chemotherapeutic agent compared to orchiectomy alone (p = 0.3).
本文呈现了一项随机试验的初步结果，该试验比较了睾丸切除术与睾丸切除术加丝裂霉素C在119例新诊断的转移性前列腺癌患者中的疗效。在109例可评估患者中，57例仅接受睾丸切除术治疗，52例接受辅助静脉注射丝裂霉素C治疗。睾丸切除术组的平均进展间隔时间为13个月，而丝裂霉素C组为11个月。初步分析表明，与单纯睾丸切除术相比，联合使用这种化疗药物并没有显示出有利效果（p = 0.3）。
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