6-羟基多巴胺体内反应产物的分离与鉴定

Isolation and identificaton of an in vivo reaction product of 6-hydroxydopamine.

作者信息

Liang Y O, Plotsky P M, Adams R N

出版信息

J Med Chem. 1977 Apr;20(4):581-3. doi: 10.1021/jm00214a026.

Abstract

The product of oxidized 6-OHDA and GSH reacted in vitro has been identified by a variety of chemical and physical methods to be 2,4,5-trihydroxy-6-S-(glutathionyl)phenethylamine. Its chemical properties show it easily undergoes a variety of oxidative condensations and polymerization. Its oxidized form, the p-quinone, can be identified in small quantities in rat brain and mouse brain 1-3 h after 6-OHDA injection. This is believed to be the first report of a chemically identified species resulting from the in vivo interaction of 6-OHDA with CNS tissue.

摘要

已通过多种化学和物理方法鉴定出，氧化型6-羟基多巴胺（6-OHDA）与谷胱甘肽（GSH）在体外反应的产物是2,4,5-三羟基-6-S-（谷胱甘肽基）苯乙胺。其化学性质表明它很容易发生各种氧化缩合和聚合反应。在注射6-OHDA后1-3小时，在大鼠脑和小鼠脑中可少量鉴定出其氧化形式对苯醌。据信，这是关于6-OHDA与中枢神经系统组织体内相互作用产生的化学鉴定物质的首次报道。