Speer K P, Warren R F
Department of Sports Medicine, Hospital for Special Surgery, New York, NY 10021.
Clin Orthop Relat Res. 1993 Jun(291):67-74.
The use of metallic implants about the shoulder joint can be complicated by loosening, migration, and breakage of the implant. Bioabsorbable implants would be an ideal solution to this problem if their bioabsorption profile could be fine tuned to appropriately share stress with the healing tissues. The development of such an implant must satisfy four basic criteria: (1) The bioabsorbable implant must have adequate initial fixation strength to coapt the soft tissues to bone; (2) The implant's bioabsorption profile must enable it to retain satisfactory strength while the healing tissues are regaining mechanical integrity; (3) The implant must not bioabsorb too slowly or it will behave like its metal counterpart with breakage and migration; and (4) The implant must be made of materials that are completely safe: no toxicity, antigenicity, pyrogenicity, or carcinogenicity.
肩关节周围使用金属植入物可能会因植入物松动、移位和断裂而变得复杂。如果生物可吸收植入物的生物吸收特性能够得到精细调整，以便与愈合组织适当地分担应力，那么它将是解决这个问题的理想方案。开发这样一种植入物必须满足四个基本标准：（1）生物可吸收植入物必须具有足够的初始固定强度，以使软组织与骨骼贴合；（2）植入物的生物吸收特性必须使其在愈合组织恢复机械完整性时能够保持令人满意的强度；（3）植入物的生物吸收速度不能过慢，否则它的行为将类似于金属植入物，出现断裂和移位；（4）植入物必须由完全安全的材料制成：无毒性、无抗原性、无致热原性或无致癌性。
