Gothard T W, Hardten D R, Lane S S, Doughman D J, Krachmer J H, Holland E J
Department of Ophthalmology, University of Minnesota, Minneapolis 55455-0501.
Am J Ophthalmol. 1993 Jun 15;115(6):729-37. doi: 10.1016/s0002-9394(14)73639-6.
The Brown-McLean syndrome is a clinical condition with corneal edema involving the peripheral 2 to 3 mm of the cornea. The edema typically starts inferiorly and progresses circumferentially, but spares the central portion of the cornea. Additionally, the edema is associated with a punctate orange-brown pigmentation on the endothelium underlying the edematous areas. Central cornea guttata is frequently seen. This condition occurs most frequently after intracapsular cataract extraction, but may also occur after extracapsular cataract extraction and phacoemulsification, or pars plana lensectomy and vitrectomy. Surgical complications and multiple intraocular procedures are frequently observed in these patients. Less frequently, the Brown-McLean syndrome can occur in eyes that have not had surgery. We studied the clinical characteristics of 43 affected eyes of 32 patients. New findings included Brown-McLean syndrome occurring in two eyes of a phakic patient with intermittent angle-closure glaucoma. Two eyes developed Brown-McLean syndrome after phacoemulsification and one eye developed peripheral edema after pars plana vitrectomy and lensectomy. Additionally, severe, infectious keratitis occurred after rupture of peripheral bullae in two eyes. Patients with this condition should be examined periodically and educated regarding the early clinical signs of corneal ulceration.
布朗 - 麦克林综合征是一种临床病症，表现为角膜水肿累及角膜周边2至3毫米区域。水肿通常始于下方，呈环形进展，但不累及角膜中央部分。此外，水肿区域下方的内皮细胞上伴有点状橙棕色色素沉着。常可见中央角膜小滴。这种情况最常见于囊内白内障摘除术后，但也可能发生在囊外白内障摘除术、超声乳化白内障吸除术，或玻璃体切割联合晶状体切除术之后。这些患者常出现手术并发症和多次眼内手术情况。较少见的是，布朗 - 麦克林综合征可发生于未接受手术的眼睛。我们研究了32例患者的43只患眼的临床特征。新发现包括：一例有晶状体眼的间歇性闭角型青光眼患者的两只眼睛出现了布朗 - 麦克林综合征；两只眼睛在超声乳化白内障吸除术后发生了布朗 - 麦克林综合征，一只眼睛在玻璃体切割联合晶状体切除术后出现了周边水肿。此外，两只眼睛周边大泡破裂后发生了严重的感染性角膜炎。患有这种病症的患者应定期接受检查，并接受有关角膜溃疡早期临床体征的教育。
