Licata G, Scaglione R, Guillet C, Capuana G, Parrinello G, Indovina A, Lipari R, Mazzola G, Merlino G
Department of Internal Medicine, University of Palermo, Italy.
J Hum Hypertens. 1993 Apr;7(2):153-7.
Clinical and renal haemodynamic parameters were evaluated in 20 mild hypertensive patients after rilmenidine (RIL) administration during a one month double-blind randomised study compared with hydrochlorothiazide (HCT). At the beginning and at the end of the study, BP, heart rate and renal haemodynamic parameters were evaluated. Renal haemodynamic parameters included effective renal plasma flow (ERPF) evaluated by radionuclide study utilising 131I-Hippuran according to Schlegel's method, effective renal blood flow (ERBF = ERPF/(1-Ht)), glomerular filtration rate (GFR) by creatinine clearance, filtration fraction (FF = GFR/ERPF) and renal vascular resistances (RVR = DBP x 80/ERBF). RIL and HCT significantly (P < 0.01) reduced systolic, diastolic and mean blood pressure without relevant change in ERPF, ERBF, GFR and FF. RVR was significantly reduced both in the RIL group (P < 0.002 vs. baseline) and in the HCT group (P < 0.001 vs. baseline). No relevant side-effects were observed in either group. In conclusion, rilmenidine was effective in reducing BP in mild hypertensive patients and produced favourable effects on renal function.
在一项为期一个月的双盲随机研究中，对20例轻度高血压患者在服用利美尼定（RIL）后与服用氢氯噻嗪（HCT）进行比较，评估了临床和肾脏血流动力学参数。在研究开始和结束时，评估血压、心率和肾脏血流动力学参数。肾脏血流动力学参数包括根据施莱格尔方法利用131I-马尿酸通过放射性核素研究评估的有效肾血浆流量（ERPF）、有效肾血流量（ERBF = ERPF/（1-Ht））、通过肌酐清除率评估的肾小球滤过率（GFR）、滤过分数（FF = GFR/ERPF）和肾血管阻力（RVR = DBP×80/ERBF）。RIL和HCT均显著（P < 0.01）降低收缩压、舒张压和平均血压，而ERPF、ERBF、GFR和FF无相关变化。RVR在RIL组（与基线相比P < 0.002）和HCT组（与基线相比P < 0.001）均显著降低。两组均未观察到相关副作用。总之，利美尼定对轻度高血压患者降低血压有效，并对肾功能产生有利影响。
