Mikamo H, Izumi K, Ito K, Sawamura H, Sawa K, Watanabe K, Ueno K, Tamaya T
Department of Obstetrics and Gynecology, School of Medicine, Gifu University.
Jpn J Antibiot. 1993 Mar;46(3):269-73.
In Japan, oral antimicrobial agents are prophylactically used with oxytocics after normal delivery to prevent puerperal infections. The present study was designed to investigate bacterial floras in the endometrial cavity immediately after normal delivery and the effect of prophylactic use of anti-microbial agents on those floras. Sixty-six puerperae who underwent uneventful courses of pregnancy and delivery were subjected for this study. Intrauterine contents were collected on the first day and the fifth day of the puerperium and submitted to microbiological examinations. Cefpodoxime proxetil (CPDX-PR) was orally given to the puerperae for prophylaxis for 5 days after the initial sampling. On the puerperal first day, a total of 98 strains (71 strains of aerobic bacteria, 27 strains of anaerobic bacteria) was detected in the uteri of the 66 subjects. The incidences of aerobic Gram-positive cocci, aerobic Gram-negative bacilli and anaerobic bacteria were 59.2%, 12.2%, 27.6% of the 98 strains, respectively. On the puerperal fifth day, a total of 82 strains (51 strains of aerobic bacteria and 31 strains of anaerobic bacteria) were detected in the uteri of the 66 subjects. The incidences of aerobic Gram-positive cocci, aerobic Gram-negative bacilli and anaerobic bacteria were 52.5%, 8.6% and 37.7% of 82 strains, respectively.
在日本，正常分娩后预防性使用口服抗菌药物与缩宫剂联用，以预防产褥感染。本研究旨在调查正常分娩后即刻子宫内膜腔内的细菌菌群，以及预防性使用抗菌药物对这些菌群的影响。66例妊娠和分娩过程顺利的产妇参与了本研究。在产褥期第一天和第五天采集宫腔内容物，并进行微生物学检查。初次采样后，给产妇口服头孢泊肟酯（CPDX-PR）进行预防，持续5天。在产褥期第一天，66例受试者的子宫中共检测到98株菌（71株需氧菌，27株厌氧菌）。需氧革兰氏阳性球菌、需氧革兰氏阴性杆菌和厌氧菌的发生率分别占98株菌的59.2%、12.2%、27.6%。在产褥期第五天，66例受试者的子宫中共检测到82株菌（51株需氧菌和31株厌氧菌）。需氧革兰氏阳性球菌、需氧革兰氏阴性杆菌和厌氧菌的发生率分别占82株菌的52.5%、8.6%和37.7%。
