Boehm G, Moro G, Minoli I
Dept. of Perinatal Pathology, Prov. Maternity Hospital, Mailand, Italien.
Kinderarztl Prax. 1993 Mar;61(2):45-7.
The influence of amino acid composition of two human milk fortifiers (Eoprotin, Milupa AG, Germany, and human albumin) on plasma amino acid profiles was studied in 28 preterm infants after a 14-day feeding period. The concentrations of total essential amino acids increased in both feeding groups significantly if compared to the period without supplementation; only the concentrations of methionine and phenylalanine in the eoprotin group and those of threonine, methionine and isoleucine in the human albumin group did not increase significantly. However, only the concentrations of isoleucine (Eoprotin: 79 +/- 19 mumol/l; human albumin: 45 +/- 20 mumol/l, p < 0.001) and methionine (Eoprotin: 26 +/- 10 mumol/l, human albumin: 16 +/- 10 mumol/l, p = 0.014) were significantly different between the two feeding groups. There was a significant correlation between the differences in the serum concentrations and the ones of each essential amino acid concentration in the fortifiers (r = 0.951). The results indicate that the amino acid composition of human milk fortifiers must be taken into consideration to achieve optimal nutritional management of preterm infants.
在28名早产儿经过14天的喂养期后，研究了两种人乳强化剂（德国Milupa AG公司的Eoprotin和人白蛋白）的氨基酸组成对血浆氨基酸谱的影响。与未补充的时期相比，两个喂养组中总必需氨基酸的浓度均显著增加；只有Eoprotin组中的蛋氨酸和苯丙氨酸浓度以及人白蛋白组中的苏氨酸、蛋氨酸和异亮氨酸浓度没有显著增加。然而，两个喂养组之间只有异亮氨酸（Eoprotin：79±19μmol/L；人白蛋白：45±20μmol/L，p<0.001）和蛋氨酸（Eoprotin：26±10μmol/L，人白蛋白：16±10μmol/L，p = 0.014）的浓度存在显著差异。血清浓度差异与强化剂中每种必需氨基酸浓度差异之间存在显著相关性（r = 0.951）。结果表明，为实现早产儿的最佳营养管理，必须考虑人乳强化剂的氨基酸组成。
