Filer R S, Song J C, Char D H, Kaleta-Michaels S
Abteilung für okulare Onkologie der Augenklinik, University of California, San Francisco.
Klin Monbl Augenheilkd. 1993 Mar;202(3):174-9. doi: 10.1055/s-2008-1045579.
Cytokines may be important in both the pathophysiology an ocular morbidity associated with treated and untreated uveal melanomas. In this study we used message amplification phenotyping to identify cytokines present in uveal melanoma samples. A number of cytokines were noted that have been associated with tumor progression, neovascularization, and inflammation in other malignancies. Interferongamma was commonly found in spindle cell tumors. Only one of 16 tumors had detectable levels of TNF-alpha and this occurred in one of two patients who developed metastatic disease.
细胞因子可能在与治疗和未治疗的葡萄膜黑色素瘤相关的病理生理学和眼部发病率中都起重要作用。在本研究中，我们使用信息扩增表型分析来鉴定葡萄膜黑色素瘤样本中存在的细胞因子。我们注意到一些细胞因子与其他恶性肿瘤中的肿瘤进展、新血管形成和炎症有关。干扰素-γ常见于梭形细胞瘤中。16个肿瘤中只有1个检测到肿瘤坏死因子-α水平，且发生在两名发生转移性疾病的患者中的1名身上。
