生长激素可使甲状腺功能减退大鼠肝脏中的肝脂酶恢复正常。

Growth hormone normalizes hepatic lipase in hypothyroid rat liver.

作者信息

Hoogerbrugge N, Jansen H, Staels B, Seip M J, Birkenhäger J C

机构信息

Department of Internal Medicine III, University Hospital Dijkzigt, Rotterdam, The Netherlands.

出版信息

Metabolism. 1993 Jun;42(6):669-71. doi: 10.1016/0026-0495(93)90230-l.

DOI:10.1016/0026-0495(93)90230-l

PMID:8510508

Abstract

The effects of growth hormone (GH) administration on hepatic lipase (HL) activity and mRNA levels were studied in pair-fed hypothyroid rats. In the hypothyroid state, liver HL mRNA levels and liver and postheparin plasma HL activities were decreased. In hypothyroid rats, GH normalized HL mRNA levels and HL activity in postheparin plasma; GH also increased the activity of HL in the liver, which remained lower than that in controls. These data indicate that at least part of the decrease of HL activity during hypothyroidism is due to the concomitant GH deficiency, and that GH rather than thyroid hormone may regulate HL mRNA levels.

摘要

在成对喂养的甲状腺功能减退大鼠中，研究了生长激素（GH）给药对肝脂肪酶（HL）活性和mRNA水平的影响。在甲状腺功能减退状态下，肝脏HL mRNA水平以及肝脏和肝素后血浆中的HL活性均降低。在甲状腺功能减退的大鼠中，GH使肝素后血浆中的HL mRNA水平和HL活性恢复正常；GH还增加了肝脏中HL的活性，但其仍低于对照组。这些数据表明，甲状腺功能减退期间HL活性降低至少部分归因于伴随的GH缺乏，并且可能是GH而非甲状腺激素调节HL mRNA水平。