Segovia S, Pérez-Laso C, Rodríguez-Zafra M, Calés J M, Del Abril A, De Blas M R, Collado P, Valencia A, Guillamón A
Departamento de Psicobiología, Universidad Nacional de Educación a Distancia, Ciudad Universitaria, Madrid, Spain.
Brain Res Bull. 1991 Jun;26(6):899-907. doi: 10.1016/0361-9230(91)90255-i.
The volume and neuron number of the sexually dimorphic accessory olfactory bulb and locus coeruleus are altered by early postnatal exposure (from the day of birth to postnatal day 16) to diazepam. After diazepam treatment, both volume and neuron number were decreased in the male accessory olfactory bulb and in the female locus coeruleus. These results indicate that early postnatal diazepam administration can bear gender-dependent teratogenic effects upon sexually dimorphic nuclei and suggest that endogenous benzodiazepines may be involved in the sexual differentiation of the brain.
出生后早期（从出生日至出生后第16天）接触地西泮会改变两性异形的副嗅球和蓝斑的体积及神经元数量。地西泮治疗后，雄性副嗅球和雌性蓝斑的体积及神经元数量均减少。这些结果表明，出生后早期给予地西泮可对两性异形核产生性别依赖性致畸作用，并提示内源性苯二氮䓬可能参与大脑的性别分化。
