Parks M M, Johnson D A, Reed G W
Department of Ophthalmology, Children's National Medical Center, Washington, DC.
Ophthalmology. 1993 Jun;100(6):826-40; discussion 840-1. doi: 10.1016/s0161-6420(93)31566-6.
Previous studies of outcome in children with aphakia have approached the data by grouping patients according to features such as age at surgery, type of procedure, or some other common attribute. The purpose of this study is to identify factors predictive for visual outcome and complications in pediatric patients with cataracts.
One hundred seventy-four eyes in 118 patients underwent lensectomy and anterior vitrectomy for congenital or juvenile cataracts. All received early optical correction, occlusion therapy when necessary, and follow-up for at least 6 months. Visual outcome and complications were analyzed statistically to determine predictive factors. Features analyzed included cataract type, laterality, age at onset, follow-up, and corneal size.
Statistical analysis showed that the most important predictor of long-term visual outcome and complications is cataract type. Visual outcome differed significantly by cataract type, with best results in the lamellar and posterior lentiglobus groups. Unilateral cases had a mean acuity lower than bilateral cases. Other factors, such as age at surgery and corneal size, were less predictive but closely linked to cataract type. Complications, such as aphakic glaucoma, also were more closely linked to the type of cataract than to other variables.
The results indicate that an important determinant of long-term outcome and complications in aphakic children is cataract type. Other features were found to be closely correlated to cataract type and were not independently significant.
以往关于无晶状体儿童预后的研究是根据手术年龄、手术类型或其他一些共同属性等特征对患者进行分组来处理数据的。本研究的目的是确定预测小儿白内障患者视觉预后和并发症的因素。
118例患者的174只眼接受了先天性或青少年性白内障的晶状体切除术和前部玻璃体切除术。所有患者均接受早期光学矫正、必要时的遮盖治疗,并随访至少6个月。对视觉预后和并发症进行统计学分析以确定预测因素。分析的特征包括白内障类型、单侧或双侧、发病年龄、随访情况和角膜大小。
统计分析表明,长期视觉预后和并发症的最重要预测因素是白内障类型。不同类型白内障的视觉预后差异显著,板层白内障和后极性晶状体球形变组的效果最佳。单侧病例的平均视力低于双侧病例。其他因素,如手术年龄和角膜大小,预测性较差,但与白内障类型密切相关。无晶状体性青光眼等并发症也与白内障类型的关系比与其他变量的关系更为密切。
结果表明,无晶状体儿童长期预后和并发症的一个重要决定因素是白内障类型。发现其他特征与白内障类型密切相关,且并非独立显著。