Sybulski S
Am J Obstet Gynecol. 1977 Apr 15;127(8):871-4. doi: 10.1016/0002-9378(77)90121-1.
Antepartum betamethasone treatment in pregnancies which terminated at less than 37 weeks of gestation resulted in a rapid and significant decrease in cord plasma cortisol levels. Mean values +/- S.E. were 5.17 +/- 0.39 microng per 100 ml. in 90 untreated cases, 2.17 +/- 0.32 microng per 100 ml. in 29 cases treated at least 24 hours prior to delivery, and 2.27 +/- 0.38 microng per 100 ml. in 18 cases in which treatment was begun within 24 hours of delivery. The mean cortisol concentration in five amniotic fluid samples obtained after betamethasone administration (0.93 +/- 0.19 microng per 100 ml.) was significantly less than in seven control samples (1.85 +/- 0.21 microng per 100 ml.) These results suggest that betamethasone suppressed endogenous cortisol production by maternal and/or fetal adrenals. However, blood cortisol levels during the first days of life of treated neonates were considerably increased in comparison to those in cord plasma, suggesting that there was rapid recovery of their adrenal function.
在妊娠不足37周时终止妊娠的孕妇中，产前使用倍他米松治疗导致脐血血浆皮质醇水平迅速且显著下降。90例未治疗病例的平均值±标准误为每100毫升5.17±0.39微克；29例在分娩前至少24小时接受治疗的病例为每100毫升2.17±0.32微克；18例在分娩后24小时内开始治疗的病例为每100毫升2.27±0.38微克。给予倍他米松后获得的5份羊水样本中的平均皮质醇浓度（每100毫升0.93±0.19微克）显著低于7份对照样本（每100毫升1.85±0.21微克）。这些结果表明，倍他米松抑制了母体和/或胎儿肾上腺的内源性皮质醇生成。然而，与脐血血浆相比，接受治疗的新生儿出生后第一天的血皮质醇水平显著升高，这表明其肾上腺功能迅速恢复。
