Kaufman R H, Binder G L, Gray P M, Adam E
Am J Obstet Gynecol. 1977 May 1;128(1):51-9. doi: 10.1016/0002-9378(77)90294-0.
Hysterosalpingograms of 60 young women exposed in utero to diethystilbestrol were obtained. In 46 instances, documentation of this exposure was obtained from the mother's chart review or confirmed by the attending physician. In 14 instances, the patients' mothers were sure they had received stilbestrol, but documentation could not be specifically confirmed. Hysterosalpingograms of 23 women being investigated for infertility during the same period that the current study was conducted were also reviewed. In 40 women exposed to stilbestrol, changes in the uterus which differed significantly from those seen in the past in nonexposed individuals were noted. These changes consisted of a 'T-shaped appearance of the uterus,' constricting bands in the uterine cavity, a hypoplastic uterus, and less frequently, intrauterine polypoid defects, synechiae, and in one instance a unicornuate uterus. In 36 of the 40 women gross defects were also noted in the cervix. By comparison, in none of the control subjects were defects noted which could be considered comparable with those seen in the DES-exposed patient.
获取了60名在子宫内接触己烯雌酚的年轻女性的子宫输卵管造影图像。在46例中，通过查阅母亲的病历记录或由主治医生确认了这种接触情况。在14例中，患者的母亲确定她们曾服用过己烯雌酚，但无法具体证实相关记录。还回顾了在本研究进行期间同时接受不孕症调查的23名女性的子宫输卵管造影图像。在40名接触己烯雌酚的女性中，观察到子宫的变化与过去未接触者明显不同。这些变化包括子宫呈“T形外观”、子宫腔内有收缩带、子宫发育不全，较少见的还有子宫内息肉样缺损、粘连，以及1例单角子宫。在这40名女性中的36名，宫颈也发现了明显缺陷。相比之下，在对照受试者中未发现可被认为与接触己烯雌酚患者所见相当的缺陷。
