肾被膜下移植在发育生物学中的应用。
Use of sub-renal capsule transplantation in developmental biology.
作者信息
Cunha Gerald R, Baskin Laurence
机构信息
Department of Urology, Box 0738, University of California, San Francisco, CA 94143, United States.
Department of Urology, Box 0738, University of California, San Francisco, CA 94143, United States.
出版信息
Differentiation. 2016 Apr-Jun;91(4-5):4-9. doi: 10.1016/j.diff.2015.10.007. Epub 2015 Nov 27.
Abstract
The sub-renal capsule graft site for in vivo growth and development of developing organs can be used to great advantage in the "rescue" of organ rudiments from "embryonic" or "birth" lethal mutant mice, which permits examination of the full impact of gene knockout in all phases of development from morphogenesis to adult functional differentiation. Another use of the sub-renal capsule graft site is the examination of normal and "chemically perturbed" development of human fetal organs. Tissue recombinants composed of various types of epithelium and mesenchyme, when grafted under the renal capsule undergo normal development and in 3-4 weeks achieve full adult functional cytodifferentiation. The investigator can control many of the developmental parameters of the graft such as endocrine status of the host and treatment of the host with a variety of biologically active agents to assess their effects on development and differentiation.
摘要
用于发育中器官体内生长和发育的肾下囊移植位点，在从“胚胎”或“出生”致死突变小鼠中“拯救”器官原基方面具有很大优势，这使得能够在从形态发生到成年功能分化的所有发育阶段检查基因敲除的全面影响。肾下囊移植位点的另一个用途是检查人类胎儿器官的正常和“化学扰动”发育。由各种类型的上皮和间充质组成的组织重组体，移植到肾囊下后会经历正常发育，并在3 - 4周内实现完全的成年功能细胞分化。研究人员可以控制移植的许多发育参数，如宿主的内分泌状态以及用各种生物活性剂对宿主进行处理，以评估它们对发育和分化的影响。
相似文献
1
Use of sub-renal capsule transplantation in developmental biology.肾被膜下移植在发育生物学中的应用。
Differentiation. 2016 Apr-Jun;91(4-5):4-9. doi: 10.1016/j.diff.2015.10.007. Epub 2015 Nov 27.
2
Developmental response of adult mammary epithelial cells to various fetal and neonatal mesenchymes.成年乳腺上皮细胞对各种胎儿和新生儿间充质的发育反应。
Epithelial Cell Biol. 1992 Jul;1(3):105-18.
3
Renal Capsule Transplantation to Assay Angiogenesis in Skeletal Development and Repair.肾被膜移植法检测骨骼发育和修复中的血管生成。
Methods Mol Biol. 2021;2230:151-165. doi: 10.1007/978-1-0716-1028-2_10.
4
Sex hormone-induced carcinogenesis in Rb-deficient prostate tissue.Rb基因缺陷型前列腺组织中的性激素诱导致癌作用。
Cancer Res. 2000 Nov 1;60(21):6008-17.
5
Mesenchymal-epithelial interaction techniques.间充质-上皮相互作用技术
Differentiation. 2016 Apr-Jun;91(4-5):20-7. doi: 10.1016/j.diff.2015.10.006. Epub 2015 Nov 21.
6
Interactions between adult human prostatic epithelium and rat urogenital sinus mesenchyme in a tissue recombination model.在组织重组模型中成年人类前列腺上皮与大鼠泌尿生殖窦间充质的相互作用。
Differentiation. 1998 Jul;63(3):131-40. doi: 10.1046/j.1432-0436.1998.6330131.x.
7
PDGFR-alpha signaling is critical for tooth cusp and palate morphogenesis.血小板衍生生长因子受体α（PDGFR-α）信号传导对于牙尖和腭部形态发生至关重要。
Dev Dyn. 2005 Jan;232(1):75-84. doi: 10.1002/dvdy.20197.
8
Development of male urogenital epithelia elicited by soluble mesenchymal factors.可溶性间充质因子引发的男性泌尿生殖上皮发育。
J Androl. 1995 May-Jun;16(3):233-41.
9
Change in morphological and functional cytodifferentiation induced by seminal vesicle mesenchyme in cell suspensions of rat Dunning prostatic adenocarcinoma cells.精囊间充质诱导大鼠邓宁前列腺腺癌细胞悬液形态和功能细胞分化的变化。
Int J Cancer. 1996 Dec 11;68(6):788-94. doi: 10.1002/(SICI)1097-0215(19961211)68:6<788::AID-IJC17>3.0.CO;2-X.
10
Role of stromal tenascin-C in mouse prostatic development and epithelial cell differentiation.基质纤连蛋白-C在小鼠前列腺发育和上皮细胞分化中的作用。
Dev Biol. 2008 Dec 15;324(2):310-9. doi: 10.1016/j.ydbio.2008.09.029. Epub 2008 Oct 10.
引用本文的文献
1
A dual-drug strategy to enhance the function of cryopreserved ovaries by promoting revascularization and inhibiting follicle over-activation.一种通过促进血管再生和抑制卵泡过度激活来增强冷冻保存卵巢功能的双药策略。
Reprod Biol Endocrinol. 2025 Jul 3;23(1):95. doi: 10.1186/s12958-025-01422-y.
2
Development of iPSC-derived human bone marrow organoid for autonomous hematopoiesis and patient-derived HSPC engraftment.用于自主造血和患者来源造血干细胞移植的诱导多能干细胞衍生的人骨髓类器官的开发。
Blood Adv. 2025 Jan 14;9(1):54-65. doi: 10.1182/bloodadvances.2024013361.
3
Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk.在完全合成的细胞外基质中构建的人类子宫内膜类器官共培养模型可用于研究上皮-间质相互作用。
Med. 2023 Aug 11;4(8):554-579.e9. doi: 10.1016/j.medj.2023.07.004.
4
Skeletal stem cells: a game changer of skeletal biology and regenerative medicine?骨骼干细胞：骨骼生物学与再生医学的变革者？
Life Med. 2022 Sep 14;1(3):294-306. doi: 10.1093/lifemedi/lnac038. eCollection 2022 Dec.
5
Differential Function and Maturation of Human Stem Cell-Derived Islets After Transplantation.人干细胞衍生胰岛移植后的功能差异和成熟。
Stem Cells Transl Med. 2022 Mar 31;11(3):322-331. doi: 10.1093/stcltm/szab013.
6
Renal subcapsular delivery of PGE promotes kidney repair by activating endogenous Sox9 stem cells.通过激活内源性Sox9干细胞，在肾被膜下递送前列腺素E可促进肾脏修复。
iScience. 2021 Oct 8;24(11):103243. doi: 10.1016/j.isci.2021.103243. eCollection 2021 Nov 19.
7
Immunosuppressed Miniswine as a Model for Testing Cell Therapy Success: Experience With Implants of Human Salivary Stem/Progenitor Cell Constructs.免疫抑制小型猪作为测试细胞治疗成功与否的模型：人唾液干/祖细胞构建体植入的经验
Front Mol Biosci. 2021 Sep 30;8:711602. doi: 10.3389/fmolb.2021.711602. eCollection 2021.
8
A comparison of prostatic development in xenografts of human fetal prostate and human female fetal proximal urethra grown in dihydrotestosterone-treated hosts.在双氢睾酮处理过的宿主中生长的人胎儿前列腺和人女性胎儿近端尿道异种移植物的前列腺发育比较。
Differentiation. 2020 Sep-Oct;115:37-52. doi: 10.1016/j.diff.2020.06.001. Epub 2020 Jul 14.
9
induction and engraftment of kidney organoids derived from human pluripotent stem cells.源自人类多能干细胞的肾类器官的诱导与植入。
Exp Ther Med. 2020 Aug;20(2):1307-1314. doi: 10.3892/etm.2020.8844. Epub 2020 Jun 5.
10
Optimizing autologous bone contribution to implant osseointegration.优化自体骨对种植体骨整合的贡献。
J Periodontol. 2020 Dec;91(12):1632-1644. doi: 10.1002/JPER.19-0524. Epub 2020 May 28.
本文引用的文献
1
Low-dose effects of hormones and endocrine disruptors.低剂量激素和内分泌干扰物的影响。
Vitam Horm. 2014;94:129-65. doi: 10.1016/B978-0-12-800095-3.00005-5.
2
Bisphenol A and human health: a review of the literature.双酚 A 与人类健康：文献综述。
Reprod Toxicol. 2013 Dec;42:132-55. doi: 10.1016/j.reprotox.2013.08.008. Epub 2013 Aug 30.
3
Role of p63 and basal cells in the prostate.p63和基底细胞在前列腺中的作用。
Development. 2004 Oct;131(20):4955-64. doi: 10.1242/dev.01384. Epub 2004 Sep 15.
4
Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis.胚胎上皮的挽救研究表明，视网膜母细胞瘤基因的纯合缺失赋予细胞生长因子非依赖性和永生化能力，但不影响上皮分化或组织形态发生。
J Biol Chem. 2002 Nov 15;277(46):44475-84. doi: 10.1074/jbc.M205361200. Epub 2002 Aug 20.
5
Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation.从小鼠乳腺上皮细胞中条件性删除bcl-x基因会导致退化过程中细胞凋亡加速，但不会损害泌乳期间的细胞功能。
Mech Dev. 2001 Dec;109(2):281-93. doi: 10.1016/s0925-4773(01)00549-4.
6
The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3.信号转导与转录激活因子3（Stat3）在细胞凋亡和乳腺退化中的作用。Stat3的条件性缺失。
Adv Exp Med Biol. 2000;480:129-38. doi: 10.1007/0-306-46832-8_16.
7
Mesenchymal reprogramming of adult human epithelial differentiation.成人人类上皮分化的间充质重编程。
Differentiation. 1999 Oct;65(2):113-8. doi: 10.1046/j.1432-0436.1999.6520113.x.
8
Assessment of prostatic protein secretion in tissue recombinants made of urogenital sinus mesenchyme and urothelium from normal or androgen-insensitive mice.对由正常或雄激素不敏感小鼠的泌尿生殖窦间充质和尿路上皮制成的组织重组体中前列腺蛋白分泌的评估。
Endocrinology. 1993 Jun;132(6):2342-50. doi: 10.1210/endo.132.6.7684975.
9
Upper genital tract changes and pregnancy outcome in offspring exposed in utero to diethylstilbestrol.子宫内暴露于己烯雌酚的后代的上生殖道变化及妊娠结局
Am J Obstet Gynecol. 1980 Jun 1;137(3):299-308. doi: 10.1016/0002-9378(80)90913-8.
10
Normal development of the human female reproductive tract and alterations resulting from experimental exposure to diethylstilbestrol.
Hum Pathol. 1982 Mar;13(3):190-8. doi: 10.1016/s0046-8177(82)80177-9.
Zotero 插件