Underwood P B, Lutz M H, Kreutner A, Miller M C, Johnson R D
Am J Obstet Gynecol. 1977 May 1;128(1):86-98. doi: 10.1016/0002-9378(77)90297-6.
A prospective study was established in August, 1967, to treat all adenocarcinomas of the endometrium by protocols of preoperative radiation followed immediately by operation. Two hundred and ninety-five women have been treated, 220 of whom had Stage I disease. In these cases, factors known to be associated with survival were studied, and their influence upon survival was noted. Preoperative radium followed immediately by operation was the primary method of therapy. Life tables demonstrated a five-year survival rate of 91 per cent with a low complication rate in patients with Stage I disease. Cell type, degree of differentiation, and depth of myomentrial invasion were the primary factors influencing survival.
1967年8月开展了一项前瞻性研究，采用术前放疗后立即手术的方案治疗所有子宫内膜腺癌。共有295名女性接受了治疗，其中220例为Ⅰ期疾病。在这些病例中，研究了已知与生存相关的因素，并记录了它们对生存的影响。术前立即进行镭疗后手术是主要的治疗方法。生命表显示，Ⅰ期疾病患者的五年生存率为91%，并发症发生率较低。细胞类型、分化程度和肌层浸润深度是影响生存的主要因素。
