Sasaki N, Saku K, Moroe K, Zhang B, Hirata K, Liu R, Arakawa K
Department of Internal Medicine, Fukuoka University School of Medicine, Japan.
Artery. 1993;20(2):115-21.
Electrocardiographic QTc intervals were measured in twenty-one hypercholesterolemic patients before and after long-term probucol (500-1,000 mg/day for 30 months) treatment. Probucol reduced serum total cholesterol (TC), triglyceride (TG), and high density lipoprotein-cholesterol (HDL-C). Mean QTc interval prolongation after probucol was 17 msec. A positive correlation was found between the change in QTc interval after probucol (delta QTc) and the total amount of probucol administered. delta QTc was negatively correlated to the pre-treatment QTc interval. No correlation was observed between serum probucol concentrations and delta QTc. Neither clinical evidence of cardiotoxicity nor critical arrhythmias were noted during the treatment period.
在21名高胆固醇血症患者接受长期普罗布考（500 - 1000毫克/天，共30个月）治疗前后，测量其心电图QTc间期。普罗布考降低了血清总胆固醇（TC）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL - C）。普罗布考治疗后平均QTc间期延长了17毫秒。发现普罗布考治疗后QTc间期的变化（△QTc）与普罗布考给药总量呈正相关。△QTc与治疗前QTc间期呈负相关。未观察到血清普罗布考浓度与△QTc之间存在相关性。在治疗期间未发现心脏毒性的临床证据或严重心律失常。
