普罗布考对QT/QT2关系及收缩期时间间期的影响。

The effects of probucol on QT/QS2 relation and systolic time intervals.

作者信息

Romics L, Littmann L, László Z, Fenyvesi T

机构信息

3rd Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.

出版信息

Int J Cardiol. 1988 Jun;19(3):303-8. doi: 10.1016/0167-5273(88)90234-3.

DOI:10.1016/0167-5273(88)90234-3

PMID:3397194

Abstract

The QT, QTc, QS2 intervals, pre-ejection period-left ventricular ejection time ratios and serum lipoprotein levels were measured in 8 patients with primary hypercholesterolemia before and after a 3-month therapy with probucol, 1 g/day. Both QT and QTc intervals increased significantly, whereas no significant changes were observed between the pre- and post-treatment QT/QS2 and pre-ejection period-left ventricular ejection time ratios. These results help to explain why treatment with probucol, while effecting a prolongation of the QTc interval, does not result in serious arrhythmias in man.

摘要

对8例原发性高胆固醇血症患者在接受每日1克普罗布考治疗3个月前后，测量其QT、QTc、QS2间期、射血前期与左心室射血时间比值以及血清脂蛋白水平。QT和QTc间期均显著增加，而治疗前后QT/QS2以及射血前期与左心室射血时间比值未观察到显著变化。这些结果有助于解释为什么普罗布考治疗虽然会使QTc间期延长，但在人体中不会导致严重心律失常。