Ohya Y, Kumamoto K, Abe I, Tsubota Y, Fujishima M
Division of Internal Medicine, Kyushu Central Hospital, Fukuoka, Japan.
Eur J Clin Pharmacol. 1993;45(1):47-52. doi: 10.1007/BF00315349.
To clarify factors related to the QT interval prolongation produced by probucol, multivariate analysis was applied to clinical and laboratory data retrospectively obtained from 89 patients with hypercholesterolaemia, who had taken probucol for more than 3 months. The corrected QT interval (QTc) increased from 0.410s before treatment to 0.431 s after the administration of probucol; the total cholesterol level decreased from 267 mg.dl-1 to 212 mg.dl-1. None of the patients demonstrated new arrhythmia. The QTc after probucol was independently correlated with sex, serum albumin level and baseline QTc. Changes in QTc after probucol were independently correlated with the presence of ischaemic heart disease, baseline QTc, and a change in the total cholesterol level. The results suggest that a prolonged QTc is likely to appear in female patients, and in patients with a long baseline QTc or with a low serum albumin. It is also suggested that marked lengthening of the QTc is likely to occur in patients with ischaemic heart disease or with a short baseline QTc. Probucol can be used safely in patients with hypercholesterolaemia, but ECG monitoring may be necessary, especially in female patients, as well as in those with hypoalbuminaemia or with ischaemic heart disease.
为了阐明与普罗布考所致QT间期延长相关的因素，我们对89例高胆固醇血症患者的临床和实验室数据进行了回顾性多变量分析，这些患者服用普罗布考超过3个月。校正QT间期（QTc）从治疗前的0.410秒增加到服用普罗布考后的0.431秒；总胆固醇水平从267mg·dl⁻¹降至212mg·dl⁻¹。所有患者均未出现新的心律失常。服用普罗布考后的QTc与性别、血清白蛋白水平和基线QTc独立相关。服用普罗布考后QTc的变化与缺血性心脏病的存在、基线QTc以及总胆固醇水平的变化独立相关。结果表明，QTc延长可能出现在女性患者、基线QTc较长或血清白蛋白水平较低的患者中。还表明，QTc显著延长可能发生在缺血性心脏病患者或基线QTc较短的患者中。普罗布考可在高胆固醇血症患者中安全使用，但可能需要进行心电图监测，尤其是女性患者以及低白蛋白血症或缺血性心脏病患者。
