Miller H, Miller B
Department of Ophthalmology, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Arch Ophthalmol. 1993 Jun;111(6):855-60. doi: 10.1001/archopht.1993.01090060145039.
Experimental subretinal neovascularization in the monkey eye was treated by photodynamic therapy with rose bengal. Following intravenous injection of rose bengal, the subretinal vessels were irradiated with filtered light. Successful treatment was achieved, provided the subretinal vessels were irradiated during the period in which the dye was present in and around the subretinal vessels but had already cleared from the retinal vasculature. The successfully treated lesions demonstrated replacement of the leaking and pooling subretinal vessels with a non-leaky scar. Morphologic evaluation revealed immediate destruction of the subretinal plexus, with minimal damage to the overlying retina. The destroyed subretinal tuft was replaced by a scar containing mainly fibroblasts embedded in collagen fibers. Our results suggest that photodynamic therapy is potentially useful for destruction of subretinal vessels without damaging the overlying retina.
用孟加拉玫瑰红进行光动力疗法治疗猴眼实验性视网膜下新生血管。静脉注射孟加拉玫瑰红后，用滤光对视网膜下血管进行照射。如果在染料存在于视网膜下血管及其周围但已从视网膜血管系统清除的期间对视网膜下血管进行照射，就能成功实现治疗。成功治疗的病变显示，渗漏和积血的视网膜下血管被无渗漏的瘢痕所取代。形态学评估显示视网膜下丛立即被破坏，而上方视网膜受损极小。被破坏的视网膜下丛被主要由嵌入胶原纤维的成纤维细胞组成的瘢痕所取代。我们的结果表明，光动力疗法在不损伤上方视网膜的情况下，对破坏视网膜下血管可能是有用的。
