Prestwood A K, Nettles V F, Farrell R L
Am J Vet Res. 1977 Apr;38(4):529-32.
Experimentally induced and naturally acquired lungworm infections (Didelphostrongylus and Capillaria) were studied in opossums, Didelphis marsupialis. Each of 4 helminth-free opossums were experimentally infected with 250 3rd-stage Didelphostrongylus hayesi larvae. At 2 and 8.5 months after infection, 2 animals were necropsied. Hypertrophy of pulmonary smooth muscle characterized D hayesi infections, with lesions pronounced in the vicinity of helminths. There was mucous bronchitis characterized by peribronchial gland hyperplasia, lymphoid nodule formation, and exudation of mucus and eosinophils into bronchioles. Lung from 4 opossums harboring natural infections of D hayesi or Capillaria or both was examined. Concomitant infections produced multifocal, indurated lesions often resulting in generalized consolidation. Microscopic examination revealed pulmonic damage consisting of hypertrophy of smooth muscle, extensive peribronchiolar adenomatoid hyperplasia of alveolar epithelium, and diffuse areas of granulomatous interstitial pneumonia. Capillaria provoked well-defined granulomas, and frequently only eggs and cuticular debris were contained within the lesions. Loss of pouch young by 1 naturally infected feamle was associated with extensive verminous pneumonia.
在绵毛负鼠（Didelphis marsupialis）中对实验诱导和自然获得的肺线虫感染（双睾线虫属和毛细线虫属）进行了研究。4只无蠕虫的负鼠每只都被实验性感染了250条第三期海氏双睾线虫幼虫。在感染后2个月和8.5个月，对2只动物进行了尸检。海氏双睾线虫感染的特征是肺平滑肌肥大，在蠕虫附近病变明显。存在黏液性支气管炎，其特征为支气管周围腺体增生、淋巴小结形成以及黏液和嗜酸性粒细胞向细支气管渗出。对4只自然感染海氏双睾线虫或毛细线虫或两者的负鼠的肺进行了检查。混合感染产生多灶性、硬结性病变，常导致广泛性实变。显微镜检查显示肺部损伤包括平滑肌肥大、肺泡上皮广泛的支气管周围腺样增生以及肉芽肿性间质性肺炎的弥漫区域。毛细线虫引发明确的肉芽肿，病变内通常仅含有虫卵和角质碎屑。1只自然感染的雌性负鼠的育儿袋幼崽死亡与广泛的蠕虫性肺炎有关。
