Yagüe A, Royo G, Satorres J, Gonzalo N, Martín C, Sevillano A
Unidad de Microbiología, Hospital Comarcal de la Vega Baja, Orihuela.
Enferm Infecc Microbiol Clin. 1993 Apr;11(4):199-201.
References about isolation of strains of Salmonella typhi multiply resistant to antimicrobials and native from Spain are very scant. We describe here two cases of typhoid fever produced by two identical strains of Salmonella typhi. Both strains are multiresistant and autochthonous, judging from epidemiological investigations.
Microbiological diagnosis was made by means of isolation of causative microorganism from blood and stool, in the first case, and only from stool, in the second one. Antimicrobial susceptibility was ascertained using a minimal inhibitory concentration micromethod.
Identification of Salmonella enterica ser. typhi and determination of its resistance to many antimicrobials. Native origin of both strains verified by means of epidemiological investigation. Healing achieved in both cases with ciprofloxacin.
We stand out the rarity of isolating native multiresistant strains of Salmonella typhi in our country, as well as the great epidemiological interest of our finding. We think that diagnosis of these diseases must be made by culturing suitable specimens and isolating causal microorganisms, what will us to determine antimicrobial susceptibility. Finally, we emphasize the resolution of the illness with ciprofloxacin. We consider that this third generation quinolone is a suitable alternative in these cases.
关于源自西班牙的多重耐药伤寒沙门氏菌菌株分离的参考文献非常稀少。我们在此描述两例由两株相同的伤寒沙门氏菌引起的伤寒热病例。根据流行病学调查判断，这两株菌株均具有多重耐药性且为本地菌株。
第一例通过从血液和粪便中分离致病微生物进行微生物学诊断，第二例仅从粪便中分离。使用微量肉汤稀释法确定抗菌药物敏感性。
鉴定出肠炎沙门氏菌血清型伤寒亚种，并确定其对多种抗菌药物的耐药性。通过流行病学调查证实两株菌株均源自本地。两例均使用环丙沙星治愈。
我们强调在我国分离出本地多重耐药伤寒沙门氏菌菌株的罕见性，以及我们这一发现的重大流行病学意义。我们认为这些疾病的诊断必须通过培养合适的标本并分离致病微生物来进行，这将有助于我们确定抗菌药物敏感性。最后，我们强调环丙沙星治愈了该疾病。我们认为这种第三代喹诺酮类药物在这些病例中是一种合适的选择。
