Bottomley W W, Yip J, Knaggs H, Cunliffe W J
Leeds Foundation for Dermatological Research, Leeds General Infirmary, UK.
Dermatology. 1993;186(4):253-7. doi: 10.1159/000247364.
Two consecutive studies were performed with the aim of clearly defining the optimal physical treatment for closed comedones. The first 10 patients with clinically significant numbers of facial comedones were treated with fulguration under EMLA anaesthesia on one side of the face and topical tretinoin on the opposite side. At the end of the study fulguration was shown to be significantly (p = 0.005) superior to topical tretinoin. A direct comparison of light electrocautery using EMLA anaesthetic with fulguration without anaesthesia was then performed on 12 patients. The comedones were subdivided by size into those that were approximately 1 mm or less in diameter and those of greater dimensions. In the treatment of larger comedones electrocautery was shown to be significantly superior to fulguration (p = 0.025), but there was no significant difference in the efficacy of the treatments for the smaller lesions.
为了明确界定闭合性粉刺的最佳物理治疗方法，进行了两项连续的研究。最初选取了10名面部粉刺数量具有临床意义的患者，在一侧面部使用EMLA麻醉下的电灼术进行治疗，另一侧面部使用外用维甲酸进行治疗。研究结束时发现，电灼术明显（p = 0.005）优于外用维甲酸。随后，对12名患者进行了使用EMLA麻醉的轻度电烙术与无麻醉电灼术的直接比较。粉刺按大小分为直径约1毫米或更小的粉刺和尺寸更大的粉刺。在治疗较大粉刺方面，电烙术明显优于电灼术（p = 0.025），但对于较小损害的治疗效果，两种治疗方法没有显著差异。
