Triantafyllou A, Harrison J D, Garrett J R
Department of Oral Pathology, Rayne Institute, King's College School of Medicine and Dentistry, London, UK.
Cell Tissue Res. 1993 May;272(2):321-7. doi: 10.1007/BF00302737.
This investigation concerns the natural history of microlith in the salivary glands of cat. Microliths were detected in more sublingual than submandibular glands and were almost absent in the parotid. They were found intraparenchymally, intraluminally and interstitially, and ultrastructurally in phagosomes of acinar, ductal and myoepithelial cells, intermixed with the cytoplasm of degenerate acinar cells, and in intraparenchymal macrophages and a multinuclear giant cell. They appear to form in healthy acinar cells during autophagocytosis, and possibly to be discharged luminally, laterally or basally, and to form in the debris of degenerate cells intraparenchymally and intraluminally. They appear to be removed by expulsion in the saliva, scavenging macrophages, and possible eventual degradation in the parenchymal phagosomes. The greater occurrence of microliths in the sublingual gland may relate to a low level of secretory activity, and the near absence of microliths in the parotid to a low level of calcium. The feline salivary glands were found to be an outstanding model for the investigation of microlithiasis.
本研究关注猫唾液腺微结石的自然病程。在舌下腺中检测到的微结石比下颌下腺更多，而在腮腺中几乎不存在。微结石在实质内、管腔内和间质中均有发现，超微结构上可见于腺泡、导管和肌上皮细胞的吞噬体中，与退化腺泡细胞的细胞质混合，也存在于实质内巨噬细胞和多核巨细胞中。它们似乎在自噬过程中于健康腺泡细胞内形成，可能经管腔、侧面或基底排出，并在实质内和管腔内退化细胞的碎片中形成。它们似乎通过随唾液排出、被巨噬细胞清除以及可能最终在实质吞噬体中降解而被清除。微结石在舌下腺中更常见可能与分泌活动水平较低有关，而在腮腺中几乎不存在则与钙水平较低有关。猫唾液腺被发现是研究微结石症的一个出色模型。
