Triantafyllou Asterios, Harrison John D, Garrett John R
Oral Pathology, School of Dental Sciences, University of Liverpool, Liverpool, UK.
Int J Exp Pathol. 2009 Aug;90(4):439-47. doi: 10.1111/j.1365-2613.2009.00645.x.
The present investigation is an attempt to determine the occurrence, elemental composition and formation of microliths in the parotid of ferret. Parotids from four normal ferrets were examined by electron microscopy and X-ray microanalysis. Crystalline microliths were found in phagosomes of acinar cells, which occasionally contained secretory material, and in phagosomes situated between mitochondria of striated ductal cells. Crystalline microliths and microliths that consisted of granular material either without crystals or mixed with a component of crystals were found in lumina, where they were often associated with cellular debris. The crystals contained calcium and phosphorus. Phagy and stagnation related to pockets of inefficient secretory activity have been previously found to be features of the parotid of ferret. Thus, possibly persistent degradation of redundant cellular material, particularly secretory granules, in phagosomes results in accumulation of calcium and leads to calcified microliths, whereas consolidation of stagnant debris extracellularly does not involve such accumulation and leads to non-calcified or mixed microliths.
本研究旨在确定雪貂腮腺中微晶的发生情况、元素组成及形成过程。对来自四只正常雪貂的腮腺进行了电子显微镜检查和X射线微分析。在腺泡细胞的吞噬体中发现了结晶微晶，这些吞噬体偶尔含有分泌物质，在纹状管细胞线粒体之间的吞噬体中也发现了结晶微晶。在管腔中发现了由无晶体的颗粒物质组成或与晶体成分混合的结晶微晶和微晶，它们通常与细胞碎片有关。这些晶体含有钙和磷。先前已发现，与分泌活动效率低下的区域相关的吞噬和停滞是雪貂腮腺的特征。因此，吞噬体中多余细胞物质（特别是分泌颗粒）可能持续降解，导致钙积累并形成钙化微晶，而细胞外停滞碎片的固结不涉及这种积累，从而导致非钙化或混合微晶的形成。
