McDuffie M, Ostrowska A
Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908.
Diabetes. 1993 Jul;42(7):1094-8. doi: 10.2337/diab.42.7.1094.
The population of T-cells that develops in any individual can be divided into families based on sequence differences in the beta-chain variable region of the T-cell receptor heterodimer. Major histocompatibility complex products and endogenous retroviral gene products have both been shown to exert powerful influences on the frequency distribution of T-cell receptor beta-chain variable region families in the mouse. In most mouse strains, these repertoire modifiers appear to be fully functional early in mouse development and shape a repertoire of antigen specificities that remains essentially unchanged from the first weeks of life until old age. In NOD mice, an inbred mouse model of type I diabetes, puberty in males coincides with a beta-chain variable region-specific T-cell expansion that mimics the results of exposure to exogenous superantigens in immunologically mature animals. The subsequent behavior of this subset indicates that it may play a role in the relative protection of male NOD mice from complete pancreatic beta-cell destruction and overt diabetes.
在任何个体中发育的T细胞群体可根据T细胞受体异二聚体β链可变区的序列差异分为不同家族。主要组织相容性复合体产物和内源性逆转录病毒基因产物均已被证明对小鼠T细胞受体β链可变区家族的频率分布有强大影响。在大多数小鼠品系中，这些谱系修饰因子在小鼠发育早期似乎就已完全发挥功能，并塑造了一套抗原特异性谱系，从生命的最初几周直到老年基本保持不变。在NOD小鼠（一种I型糖尿病的近交小鼠模型）中，雄性小鼠的青春期与β链可变区特异性T细胞扩增同时发生，这类似于免疫成熟动物接触外源性超抗原的结果。该亚群随后的行为表明，它可能在雄性NOD小鼠相对保护胰腺β细胞免受完全破坏和显性糖尿病方面发挥作用。
