石棉相关间皮瘤和非石棉相关间皮瘤中p53免疫染色的频率。

The frequency of p53 immunostaining in asbestos-associated mesotheliomas and non-asbestos-associated mesotheliomas.

作者信息

Mayall F G, Goddard H, Gibbs A R

机构信息

Department of Histopathology, Llandough Hospital, Penarth, South Glamorgan, UK.

出版信息

Histopathology. 1993 Apr;22(4):383-6. doi: 10.1111/j.1365-2559.1993.tb00140.x.

DOI:10.1111/j.1365-2559.1993.tb00140.x

PMID:8514283

Abstract

It has been suggested that asbestos might have an important role in the development of p53 mutations in mesotheliomas. The objective of this study was to examine asbestos-associated mesotheliomas and non-asbestos-associated mesotheliomas to establish whether the frequency of p53 immunostaining and, by implication, p53 gene mutation is related to asbestos exposure. Immunopositivity for p53 was found in seven (44%) of the 16 mesotheliomas examined. The frequency was approximately the same in both the asbestos-associated mesotheliomas and the non-asbestos-associated mesotheliomas. It is concluded that the frequency of p53 immunostaining in mesotheliomas and, by implication, the frequency of p53 gene mutation is probably not related to asbestos exposure.

摘要

有人认为，石棉可能在间皮瘤中p53突变的发生过程中起重要作用。本研究的目的是检查石棉相关间皮瘤和非石棉相关间皮瘤，以确定p53免疫染色的频率以及p53基因突变频率是否与石棉暴露有关。在所检查的16例间皮瘤中，有7例（44%）发现p53免疫阳性。石棉相关间皮瘤和非石棉相关间皮瘤中的频率大致相同。得出的结论是，间皮瘤中p53免疫染色的频率以及p53基因突变频率可能与石棉暴露无关。