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苏格兰的哮喘:流行病学与临床管理

Asthma in Scotland: epidemiology and clinical management.

作者信息

Capewell S

机构信息

St Andrew's House, Edinburgh.

出版信息

Health Bull (Edinb). 1993 Mar;51(2):118-27.

PMID:8514488
Abstract

Asthma in Scotland is briefly reviewed including epidemiology, management and the potential for research, education and audit. Asthma is characterised by variable wheeze and shortness of breath caused by variable narrowing of the bronchial airways secondary to inflammation. Confusion with chronic obstructive airways disease is increasingly common in the elderly and epidemiological studies tend to focus on the age range 5-44 years. Asthma prevalence is critically dependent on the definitions used and exceeds 20% based on questionnaire alone, less if objective measurements of airways obstruction is also used: perhaps 15% in children, 5% in adults in Scotland. Comparisons between studies and countries are therefore potentially hazardous. Routine information sources confirm the high levels of morbidity and use of health services by asthmatic patients. A true increase in the prevalence of asthma in children over the last two decades appears likely. This has been compounded by increased willingness to use the diagnostic label of asthma. Asthma, hayfever and eczema have increased significantly in Aberdeen school children over the last 25 years and asthma symptoms and airways obstruction have increased significantly in South Wales. Similar increases are reported in New Zealand children between 1975 and 1985, the prevalence being significantly higher than in Welsh children using standardised methodology. In Zimbabwe an intriguing strong association has been demonstrated between asthma, urban life style and higher socio economic groups. Most asthma deaths are caused by bronchial narrowing and subsequent asphyxia. Asthma mortality has apparently increased in most industrialised countries but problems of definition remain even when attention is confined to the age span 5-44 years. The epidemic of asthma deaths in mid-60s was undeniable and may have reflected good symptomatic control by bronchodilators, which made doctors and patients neglect the underlying risk of asthma death. A gradual increase in asthma mortality in western countries over the 1970s and 1980s is apparent, including almost 5% annual increase in England and Wales between 1974 and 1984 which then levelled off. This may again reflect excess dependence on bronchodilator treatment and under-usage of steroid treatment. A more dramatic increase in mortality in New Zealand in the early 1980s is likely to have a number of contributory factors. In contrast, the mortality rate in Scotland had been relatively static over the last two decades, although hospital discharge rates have doubled. Emergency asthma self admission schemes developed in Edinburgh are increasing popular and these, along with nebulised bronchodilators in ambulances, may be beneficial.(ABSTRACT TRUNCATED AT 400 WORDS)

摘要

本文简要回顾了苏格兰的哮喘情况,包括流行病学、管理以及研究、教育和审计的潜力。哮喘的特征是由于炎症导致支气管气道可变狭窄而引起的可变喘息和呼吸急促。在老年人中,与慢性阻塞性气道疾病的混淆越来越常见,流行病学研究往往集中在5 - 44岁的年龄范围。哮喘患病率严重依赖于所使用的定义,仅基于问卷调查时超过20%,若同时使用气道阻塞的客观测量则患病率较低:在苏格兰,儿童中可能为15%,成人中为5%。因此,不同研究和国家之间的比较可能存在风险。常规信息来源证实哮喘患者的发病率和卫生服务利用率很高。在过去二十年中,儿童哮喘患病率似乎确实有所上升。而对哮喘诊断标签使用意愿的增加使情况更加复杂。在过去25年里,阿伯丁学童的哮喘、花粉热和湿疹显著增加,南威尔士的哮喘症状和气道阻塞也显著增加。1975年至1985年间,新西兰儿童也有类似的增加,采用标准化方法得出的患病率明显高于威尔士儿童。在津巴布韦,已证明哮喘、城市生活方式和较高社会经济群体之间存在有趣的强关联。大多数哮喘死亡是由支气管狭窄和随后的窒息引起的。在大多数工业化国家,哮喘死亡率显然有所上升,但即使将注意力局限于5 - 44岁年龄范围,定义问题仍然存在。60年代中期的哮喘死亡流行是不可否认的,这可能反映了支气管扩张剂对症状的良好控制,使医生和患者忽视了哮喘死亡的潜在风险。在20世纪70年代和80年代,西方国家哮喘死亡率逐渐上升,包括1974年至1984年间英格兰和威尔士每年近5%的上升,随后趋于平稳。这可能再次反映了对支气管扩张剂治疗的过度依赖和类固醇治疗的使用不足。20世纪80年代初,新西兰死亡率的更显著上升可能有多种促成因素。相比之下,在过去二十年中,苏格兰的死亡率相对稳定,尽管医院出院率翻了一番。爱丁堡开展的哮喘急诊自助入院计划越来越受欢迎,这些计划以及救护车上的雾化支气管扩张剂可能会有所帮助。(摘要截选至400字)

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