Hopkins R J, Vial P A, Ferreccio C, Ovalle J, Prado P, Sotomayor V, Russell R G, Wasserman S S, Morris J G
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201.
J Infect Dis. 1993 Jul;168(1):222-6. doi: 10.1093/infdis/168.1.222.
Helicobacter pylori infection is very common in Chilean adults, but the age-related prevalence, risk factors for infection, and mode of transmission in Chilean children are unknown. An ELISA was used to test for H. pylori antibodies in 1815 Chileans < 35 years of age. Seropositivity was > 60% in lower socioeconomic groups. H. pylori seropositivity correlated with increased age, low socioeconomic status, and consumption of uncooked vegetables by use of a logistic regression analysis. Risk factors that reached marginal significance were consumption of uncooked shell-fish, female sex, and residence in Santiago. Although multiple modes of transmission for H. pylori undoubtedly exist, prior studies have suggested that contamination of irrigation water by raw sewage (and the subsequent contamination of vegetables that are eaten uncooked) is a key factor in the transmission of enteric pathogens in Chile; H. pylori may be transmitted by a similar route.
幽门螺杆菌感染在智利成年人中非常普遍，但智利儿童中与年龄相关的感染率、感染风险因素及传播方式尚不清楚。采用酶联免疫吸附测定法（ELISA）检测了1815名35岁以下智利人的幽门螺杆菌抗体。社会经济地位较低群体的血清阳性率>60%。通过逻辑回归分析，幽门螺杆菌血清阳性与年龄增长、社会经济地位低下及食用生蔬菜有关。具有边缘显著性的风险因素是食用生贝类、女性性别以及居住在圣地亚哥。尽管幽门螺杆菌无疑存在多种传播方式，但先前的研究表明，未经处理的污水污染灌溉用水（以及随后对未煮熟食用蔬菜的污染）是智利肠道病原体传播的一个关键因素；幽门螺杆菌可能通过类似途径传播。
