• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

椎间盘中天冬氨酸消旋化用于死后死亡年龄估计

Aspartic acid racemization in intervertebral discs as an aid to postmortem estimation of age at death.

作者信息

Ritz S, Schütz H W

机构信息

Institut für Rechtsmedizin, Christian-Albrechts-Universität zu Kiel, Germany.

出版信息

J Forensic Sci. 1993 May;38(3):633-40.

PMID:8515214
Abstract

We investigated whether measurement of aspartic acid racemization in intervertebral discs (IVD) could be used in the postmortem estimation of age at death. The extent of aspartic acid racemization in IVD tissues was found to increase with age. The rate of racemization turned out to be much higher in the nucleus pulposus than in the annulus fibrosus. The relation between age and the D-aspartic acid content in the anterior peripheral annulus fibrosus of IVD was close enough to allow postmortem estimation of age at death based on the extent of aspartic acid racemization in this tissue.

摘要

我们研究了椎间盘(IVD)中天冬氨酸消旋化的测量是否可用于死后死亡年龄的估计。发现IVD组织中天冬氨酸消旋化的程度随年龄增长而增加。结果表明,髓核中的消旋化速率比纤维环中的要高得多。IVD前外侧纤维环中年龄与D-天冬氨酸含量之间的关系足够密切,足以根据该组织中天冬氨酸消旋化的程度对死后死亡年龄进行估计。

相似文献

1
Aspartic acid racemization in intervertebral discs as an aid to postmortem estimation of age at death.椎间盘中天冬氨酸消旋化用于死后死亡年龄估计
J Forensic Sci. 1993 May;38(3):633-40.
2
Age-related changes in proteoglycans of human intervertebral discs.人类椎间盘蛋白聚糖的年龄相关变化。
Z Rheumatol. 1994 Jan-Feb;53(1):19-25.
3
[Estimation of age from teeth using the racemization of aspartic acid (racemization method)].[利用天冬氨酸消旋化(消旋化法)从牙齿估计年龄]
Nihon Hoigaku Zasshi. 2000 Aug;54(2):207-18.
4
Studies on age estimation using racemization of aspartic acid in cementum.利用牙骨质中天冬氨酸消旋化进行年龄估计的研究。
J Forensic Sci. 1995 Sep;40(5):805-7.
5
Degradation of biomolecules in artificially and naturally aged teeth: implications for age estimation based on aspartic acid racemization and DNA analysis.人工老化和自然老化牙齿中生物分子的降解:对基于天冬氨酸消旋化和DNA分析的年龄估计的影响。
Forensic Sci Int. 2008 Aug 6;179(2-3):181-91. doi: 10.1016/j.forsciint.2008.05.017. Epub 2008 Jul 14.
6
Age estimation by measuring the racemization of aspartic acid from total amino acid content of several types of bone and rib cartilage: a preliminary account.通过测量几种类型的骨骼和肋软骨总氨基酸含量中天冬氨酸的消旋作用来估计年龄:初步报告。
J Forensic Sci. 2002 Jan;47(1):32-6.
7
Evolution of disc degeneration in lumbar spine: a comparative histological study between herniated and postmortem retrieved disc specimens.腰椎间盘退变的演变:突出椎间盘标本与死后获取椎间盘标本的组织学对比研究
J Spinal Disord. 1998 Feb;11(1):41-5.
8
DR5 and DcR2 are expressed in human lumbar intervertebral discs.DR5和DcR2在人类腰椎椎间盘中表达。
Spine (Phila Pa 1976). 2009 Sep 1;34(19):E677-81. doi: 10.1097/BRS.0b013e3181b4d4ee.
9
Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrity.与基质组成和完整性相关的椎间盘表观扩散系数
Magn Reson Imaging. 2004 Sep;22(7):963-72. doi: 10.1016/j.mri.2004.02.011.
10
Feasibility of a stem cell therapy for intervertebral disc degeneration.一种用于椎间盘退变的干细胞疗法的可行性。
Spine J. 2008 Nov-Dec;8(6):888-96. doi: 10.1016/j.spinee.2007.09.011. Epub 2007 Dec 21.

引用本文的文献

1
Application of Aspartic Acid Racemization for Age Estimation in a Spanish Sample.天冬氨酸消旋化在西班牙样本年龄估计中的应用。
Biology (Basel). 2022 Jun 3;11(6):856. doi: 10.3390/biology11060856.
2
Age estimation based on aspartic acid racemization in dentine: what about caries-affected teeth?基于牙本质中天冬氨酸消旋化的年龄估计:那么受龋影响的牙齿呢?
Int J Legal Med. 2018 Mar;132(2):623-628. doi: 10.1007/s00414-017-1667-6. Epub 2017 Aug 19.
3
Age estimation based on aspartic acid racemization in human sclera.基于人巩膜中天冬氨酸消旋化的年龄估计。
Int J Legal Med. 2016 Jan;130(1):207-11. doi: 10.1007/s00414-015-1255-6. Epub 2015 Aug 25.
4
Estimation of age at death based on aspartic acid racemization in elastic cartilage of the epiglottis.基于会厌弹性软骨中天冬氨酸消旋化对死亡年龄的估计。
Int J Legal Med. 2014 Nov;128(6):995-1000. doi: 10.1007/s00414-013-0940-6. Epub 2013 Nov 12.
5
Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc.正常和退变椎间盘细胞外基质的生化组成与更新
Eur Spine J. 2014 Jun;23 Suppl 3:S344-53. doi: 10.1007/s00586-013-2767-8. Epub 2013 Apr 17.
6
Racemization of two proteins over our lifespan: deamidation of asparagine 76 in γS crystallin is greater in cataract than in normal lenses across the age range.两种蛋白质在我们一生中的外消旋化:γS 晶体蛋白中 76 位天冬酰胺的脱酰胺作用在白内障晶状体中比在正常晶状体中更为常见,跨越整个年龄段。
Invest Ophthalmol Vis Sci. 2012 Jun 14;53(7):3554-61. doi: 10.1167/iovs.11-9085.
7
Racemisation and human cataract. D-Ser, D-Asp/Asn and D-Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lenses.消旋作用与人类白内障。在白内障晶状体的终身蛋白质中,D-丝氨酸、D-天冬氨酸/天冬酰胺和D-苏氨酸的含量高于年龄匹配的正常晶状体。
Age (Dordr). 2011 Jun;33(2):131-41. doi: 10.1007/s11357-010-9171-7. Epub 2010 Aug 5.
8
Aspartic acid racemisation in purified elastin from arteries as basis for age estimation.从动脉中纯化的弹性蛋白中天门冬氨酸的外消旋化作为年龄估计的基础。
Int J Legal Med. 2010 Jul;124(4):269-75. doi: 10.1007/s00414-009-0392-1. Epub 2009 Nov 19.
9
Age estimation based on aspartic acid racemization in elastin from the yellow ligaments.基于黄韧带弹性蛋白中天冬氨酸消旋化的年龄估计
Int J Legal Med. 2003 Apr;117(2):96-101. doi: 10.1007/s00414-002-0355-2. Epub 2003 Feb 28.
10
Predicting protein decomposition: the case of aspartic-acid racemization kinetics.预测蛋白质分解:天冬氨酸消旋动力学的案例
Philos Trans R Soc Lond B Biol Sci. 1999 Jan 29;354(1379):51-64. doi: 10.1098/rstb.1999.0359.