de Lalla F, Scalambrino S, Tassi P G, Alegente G, Conturso R, Doregatti L, Archetti L, Pollini F, Zanella G C, Demaria E
Division of Infectious Diseases, S. Bortolo Hospital, Vicenza, Italy.
J Chemother. 1993 Apr;5(2):113-8. doi: 10.1080/1120009x.1993.11739218.
Five hundred and sixty-six women, consecutively admitted to nine different hospitals for elective abdominal hysterectomy, were randomized to receive a single 2 g i.v. dose of either cefotetan or piperacillin at induction of anesthesia. Five patients were excluded and 561 (287 given cefotetan and 274 given piperacillin) could be evaluated. In 10 patients (5 for each drug) the concentrations of either cefotetan or piperacillin in serum and subcutaneous tissue at the beginning and at the end of surgery and in uterus, salpinx and ovary samples, were microbiologically assessed. No significant differences could be found between cefotetan and piperacillin groups for any of the considered infectious complications (bacteremia, wound or vaginal cuff infection, pelvic cellulitis and febrile morbidity) nor for the pooled data (cefotetan group: 4.9%, piperacillin group: 5.8%, p:NS). As for the concentrations of prophylactic drugs, serum levels throughout surgery were found to be adequate.
566名连续入住9家不同医院接受择期腹部子宫切除术的女性，在麻醉诱导时被随机分为两组，分别接受单次静脉注射2克头孢替坦或哌拉西林。5名患者被排除，561名（287名给予头孢替坦，274名给予哌拉西林）可进行评估。对10名患者（每种药物5名）手术开始和结束时血清、皮下组织以及子宫、输卵管和卵巢样本中头孢替坦或哌拉西林的浓度进行了微生物学评估。在任何一种考虑的感染性并发症（菌血症、伤口或阴道残端感染、盆腔蜂窝织炎和发热性疾病）方面，头孢替坦组和哌拉西林组之间均未发现显著差异，汇总数据也无差异（头孢替坦组：4.9%，哌拉西林组：5.8%，p：无统计学意义）。至于预防性药物的浓度，整个手术过程中的血清水平被认为是足够的。
