McNeil T F, Harty B, Blennow G, Cantor-Graae E
Department of Psychiatry, University of Lund, Malmö, Sweden.
J Psychiatr Res. 1993 Jan-Mar;27(1):39-54. doi: 10.1016/0022-3956(93)90048-7.
As part of a longitudinal investigation begun in the neonatal period, selected neuromotor behaviors and different facets of general mental development were investigated blind at 6 years of age in 64 index offspring of women with a history of schizophrenic, schizoaffective, affective and unspecified functional psychosis and in 95 control offspring of women with no history of psychosis. Compared with the controls, the offspring of psychotics (total index group) showed a significantly increased frequency of both multiple and specific neuromotor deviations. The offspring of women with schizophrenia and with unspecified functional psychosis showed increased rates of multiple neuromotor deviations, not found in the offspring of women with schizoaffective and affective psychoses. The neuromotor deviations were confirmed on Griffiths Developmental Test subscales reflecting gross and fine motor performance, and the deficits did not extend to subscales measuring cognitive ability and personal-social competence. No relationship was found between the individual subject's neonatal and 6-year deviation scores. The results suggest the existence of a selective neuromotor developmental deviation in the offspring of schizophrenics and women with unspecified functional psychosis. Different possible etiological factors are discussed.
作为一项始于新生儿期的纵向研究的一部分，对64名有精神分裂症、分裂情感性障碍、情感性障碍及未特定的功能性精神病病史女性的子代和95名无精神病病史女性的对照子代在6岁时进行了盲法评估，调查了选定的神经运动行为和一般智力发育的不同方面。与对照组相比，精神病患者的子代（总指数组）表现出多种和特定神经运动偏差的频率显著增加。患有精神分裂症和未特定功能性精神病女性的子代表现出多种神经运动偏差率增加，而患有分裂情感性障碍和情感性精神病女性的子代未出现这种情况。神经运动偏差在反映粗大和精细运动表现的格里菲斯发育测试子量表上得到证实，且缺陷未扩展到测量认知能力和个人社交能力的子量表。个体受试者的新生儿期和6岁时的偏差得分之间未发现关联。结果表明，精神分裂症患者和未特定功能性精神病女性的子代存在选择性神经运动发育偏差。讨论了不同的可能病因。
