Isobe H, Iwata S, Fujime M, Kitagawa R
Department of Urology, Juntendo University School of Medicine.
Nihon Hinyokika Gakkai Zasshi. 1993 Mar;84(3):457-62. doi: 10.5980/jpnjurol1989.84.457.
In recent years, it has become clear that various extracellular substrates play an important role in the process of invasion and metastasis of malignant tumors. In a previous study, we reported that the serum concentration of laminin in renal cell carcinoma and prostate cancer is elevated, and furthermore, is remarkably high in patients with metastasis. However, in bladder cancer, this level is elevated only in those with metastasis, indicating that the serum concentration of laminin is useful as a marker for metastasis or clinical progression of the malignant tumor. In the present study, we measured the serum concentration of type IV collagen 7S-domain, which, as laminin constructs the basement membrane, and compared the result with the serum concentration of laminin, to evaluate the clinical significance of the findings. The serum concentration of type IV collagen 7S-domain was not elevated significantly in any tumor type, although the serum concentration of laminin was elevated in patients with renal cell carcinoma, prostate cancer and bladder cancer with metastasis. There were no significant differences in the serum concentration of type IV collagen 7S-domain in any group with metastasis.
近年来，各种细胞外基质在恶性肿瘤侵袭和转移过程中发挥重要作用已变得清晰。在之前的一项研究中，我们报道肾细胞癌和前列腺癌患者血清层粘连蛋白浓度升高，此外，发生转移的患者血清层粘连蛋白浓度显著升高。然而，在膀胱癌中，仅发生转移的患者该水平升高，这表明血清层粘连蛋白浓度可作为恶性肿瘤转移或临床进展的标志物。在本研究中，我们检测了IV型胶原7S结构域的血清浓度，其与层粘连蛋白共同构成基底膜，并将结果与层粘连蛋白的血清浓度进行比较，以评估这些发现的临床意义。尽管肾细胞癌、前列腺癌和发生转移的膀胱癌患者血清层粘连蛋白浓度升高，但IV型胶原7S结构域的血清浓度在任何肿瘤类型中均未显著升高。在任何发生转移的组中，IV型胶原7S结构域的血清浓度均无显著差异。
