Maruyama Y, Hirata N, Yamada H, Sasaki K, Motomiya Y, Hirao Y, Okajima E
Department of Urology, Matsusaka Chuo Hospital.
Nihon Hinyokika Gakkai Zasshi. 1993 Mar;84(3):541-5. doi: 10.5980/jpnjurol1989.84.541.
Thirty-one patients (26 male and 5 female patients) of non-hypercalciuric Ca stone formers were studied concerning their bone metabolism. We measured plasma free gamma-carboxyglutamic acid, plasma hydroxyproline, urinary free gamma-carboxyglutamic acid and urinary hydroxyproline as markers of bone metabolism. Plasma free gamma-carboxyglutamic acid level showed significantly higher in stone formers than normal controls (1.01 +/- 0.37 nmol/ml vs 0.39 +/- 0.13 nmol/ml). But no significant difference were observed in plasma hydroxyproline level (1.99 +/- 0.73 micrograms/ml vs 2.27 +/- 0.92 micrograms/ml), urinary free gamma-carboxyglutamic acid (52.0 +/- 17.6 nmol/mg.Cr vs 45.7 +/- 9.8 nmol/mg.Cr), and urinary hydroxyproline (3.87 +/- 2.02 micrograms/mg.Cr vs 3.33 +/- 1.63 micrograms/mg.Cr). In conclusion, these results suggest that abnormality of bone metabolism may be not a primary event in causing stone formation in these patients.
对31例非高钙尿性钙结石形成者（26例男性和5例女性患者）的骨代谢情况进行了研究。我们测定了血浆游离γ-羧基谷氨酸、血浆羟脯氨酸、尿游离γ-羧基谷氨酸和尿羟脯氨酸作为骨代谢标志物。结石形成者的血浆游离γ-羧基谷氨酸水平显著高于正常对照组（分别为1.01±0.37nmol/ml和0.39±0.13nmol/ml）。但血浆羟脯氨酸水平（分别为1.99±0.73μg/ml和2.27±0.92μg/ml）、尿游离γ-羧基谷氨酸（分别为52.0±17.6nmol/mg.Cr和45.7±9.8nmol/mg.Cr）以及尿羟脯氨酸（分别为3.87±2.02μg/mg.Cr和3.33±1.63μg/mg.Cr）均未观察到显著差异。总之，这些结果表明骨代谢异常可能不是这些患者结石形成的主要原因。
