Mezhlumian A A
Biull Eksp Biol Med. 1977 Jan;83(1):77-80.
Post-traumatic regeneration of the rat spleen was studied after resection of half the organ, under gravitation overloading (11 units) using spleen tissue extract prepared by Filatov's method. Gravitation overloading caused a decrease in the size of the spleen nodules, smooths their contours, increases the red pulp infiltration by the lymphocytes, reduces the number of labeled cells and the intensity of the label in the reactive centers of the spleen nodules, decelerates the capsule formation in the resection area. Application of the stimulant normalized the structure of white pulp, increased the number of labeled cells, and accelerated the capsule formation. The tissue extract used in gravitation overloading brought the restoration process nearer to the usual course of the posttraumatic spleen regeneration (by the character and periods of tissue differentiation development).
在重力过载（11个单位）条件下，采用菲拉托夫方法制备的脾组织提取物，研究大鼠脾脏切除一半后的创伤后再生情况。重力过载导致脾小结尺寸减小，轮廓变平滑，淋巴细胞对红髓的浸润增加，脾小结反应中心标记细胞数量及标记强度降低，切除区域的包膜形成减慢。应用刺激剂可使白髓结构正常化，增加标记细胞数量，并加速包膜形成。重力过载时使用的组织提取物使恢复过程更接近创伤后脾脏再生的正常进程（就组织分化发育的特征和时期而言）。
