Mezhlumian A A
Biull Eksp Biol Med. 1977 Aug;84(8):224-7.
Different forms of megakaryocytes are found in the intact spleen of rats, with ring-like nucleus and in the form of multinuclear large cells. The division of megakaryocytes takes place by multipolar mitosis without any subsequent cytotomy. During the regeneration the megakaryocyte count and their mitotic activity displayed a sharp increase. The gravitation overload increased the megakaryocyte count and their mitotic activity even more. The use of the spleen extracts against the background of gravitation overload diminished the megakaryocyte count, but increased their mitotic activity. In hypokinetic conditions the number of megakaryocytes was sharply decreased and no mitoses were seen in these cells.
在大鼠完整的脾脏中可发现不同形态的巨核细胞，有环状核且呈多核大细胞形态。巨核细胞通过多极有丝分裂进行分裂，之后不发生胞质分裂。在再生过程中，巨核细胞数量及其有丝分裂活性急剧增加。重力过载使巨核细胞数量及其有丝分裂活性增加得更多。在重力过载背景下使用脾脏提取物可减少巨核细胞数量，但增加其有丝分裂活性。在运动不足的情况下，巨核细胞数量急剧减少，且在这些细胞中未见有丝分裂。
