自闭症儿童血小板中的血清素和氨基酸含量
Serotonin and amino acid content in platelets of autistic children.
作者信息
Rolf L H, Haarmann F Y, Grotemeyer K H, Kehrer H
机构信息
Department of Neurology, University of Münster, Germany.
出版信息
Acta Psychiatr Scand. 1993 May;87(5):312-6. doi: 10.1111/j.1600-0447.1993.tb03378.x.
The platelet levels of serotonin and the amino acids aspartic acid, glutamine, glutamic acid and gamma-aminobutyric acid were measured in 18 drug-free autistic (DSM-III criteria) and 14 age-matched healthy children. Serotonin was significantly increased while the amino acids aspartic acid, glutamine, glutamic acid and gamma-aminobutyric acid were significantly decreased in comparison with the controls. It is suggested that the decline of the amino acids in platelets from autistic children represents a biochemical marker related to infantile autism.
对18名未服用药物的自闭症儿童（符合DSM-III标准）和14名年龄匹配的健康儿童的血小板中血清素以及天冬氨酸、谷氨酰胺、谷氨酸和γ-氨基丁酸等氨基酸水平进行了测量。与对照组相比，自闭症儿童的血清素显著升高，而天冬氨酸、谷氨酰胺、谷氨酸和γ-氨基丁酸等氨基酸则显著降低。研究表明，自闭症儿童血小板中氨基酸水平的下降代表了一种与婴儿自闭症相关的生化标志物。
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